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AB171799

Anti-RND3 antibody

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(4 Publications)

Mouse Polyclonal RND3 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RND3.

View Alternative Names

ARHE, RHO8, RHOE, RND3, Rho-related GTP-binding protein RhoE, Protein MemB, Rho family GTPase 3, Rho-related GTP-binding protein Rho8, Rnd3

1 Images
Western blot - Anti-RND3 antibody (AB171799)
  • WB

Supplier Data

Western blot - Anti-RND3 antibody (AB171799)

All lanes:

Western blot - Anti-RND3 antibody (ab171799) at 1 µg/mL

Lane 1:

RND3 transfected 293T cell lysate

Lane 2:

Non-transfected 293T cell lysate

Predicted band size: 27 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human RND3.

P61587

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RND3 also known as RhoE is a small GTPase with a molecular mass of approximately 25 kDa. It belongs to the Rho family of GTPases. RND3 lacks intrinsic GTPase activity which makes it constantly bound to GTP. This protein gets expressed in several tissues including the brain heart and skeletal muscles. By interfering with the actin cytoskeleton RND3 regulates cell shape and movement.
Biological function summary

The functions of RND3 involve the regulation of the cytoskeleton contributing to processes such as cell adhesion and migration. RND3 operates independently not forming part of a larger protein complex yet it plays a pivotal role in modulating the activity of other signaling molecules. Its influence on the cytoskeleton makes it an important player in maintaining cellular architecture and dynamics which is fundamental for tissue integrity and repair.

Pathways

RND3 is intricately involved in the MAPK and PI3K/AKT signaling pathways. These pathways are essential for cell growth migration and survival. RND3 interacts with proteins such as ROCK1 and ROCK2 in these pathways affecting downstream activities positively or negatively. The regulation of these signaling cascades by RND3 shows its importance in cellular responses to environmental cues.

RND3 is linked to cancer and cardiovascular diseases. Alterations in RND3 expression or function can contribute to the uncontrolled cell proliferation seen in various cancers. In cancer its interactions with signaling proteins like AKT lead to enhanced survival signaling. In the context of cardiovascular diseases RND3 influences vascular smooth muscle cell behavior impacting atherosclerosis progression. Through these connections RND3 emerges as a significant target for therapeutic research.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.
See full target information RND3
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 15:931 PubMed39719443

2024

Mechanistic insights into SIRT7 and EZH2 regulation of cisplatin resistance in bladder cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yudong Cao,Shuo Wang,Jinchao Ma,Mengping Long,Xiuli Ma,Xiao Yang,Yongpeng Ji,Xingxing Tang,Jia Liu,Chen Lin,Yong Yang,Peng Du

Oncogene 40:6329-6342 PubMed34433909

2021

Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients.

Applications

Unspecified application

Species

Unspecified reactive species

M Kathryn Leonard,Gemma S Puts,Nidhi Pamidimukkala,Gautam Adhikary,Yili Xu,Eric Kwok,Yuxin Jin,Devin Snyder,Nicolette Matsangos,Marián Novak,Anup Mahurkar,Amol C Shetty,Radomir M Slominski,Edward C De Fabo,Frances P Noonan,Chi-Ping Day,Mohammed Rigi,Andrzej T Slominski,Michelle G Webb,David W Craig,Glenn Merlino,Richard L Eckert,John D Carpten,Zarko Manojlovic,David M Kaetzel

Diabetes 69:689-698 PubMed31949005

2020

Retinopathy in a Diet-Induced Type 2 Diabetic Rat Model and Role of Epigenetic Modifications.

Applications

Unspecified application

Species

Unspecified reactive species

Renu A Kowluru

RSC advances 8:34973-34983 PubMed35547072

2018

Retracted Article: MiR-182-5p and miR-96-5p increased hepatocellular carcinoma cell mobility, proliferation and cisplatin resistance partially by targeting RND3.

Applications

Unspecified application

Species

Unspecified reactive species

Shiming Yang,Zhi Chen,Daguang Fan,Rui Zhang,Yuhong Zhang,Shusheng Wu
View all publications
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