Anti-RNF123 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

RNF123 modulates cellular function through its ability to control protein turnover. As part of the Skp1-Cullin-F-box (SCF) complex it influences cellular processes such as the cell cycle by regulating proteolytic degradation of proteins. The ligase activity of RNF123 directly contributes to the balance of cellular components impacting cell cycle progression and apoptosis regulation. Its involvement in apoptotic pathways captures attention where it influences cell survival by targeting specific substrates for degradation.

Pathways

RNF123 interacts within the ubiquitin-proteasome pathway and the cell cycle regulation pathways. By fine-tuning the degradation of cyclins and cyclin-dependent kinase inhibitors RNF123 works closely with proteins such as Skp1 and Cullin to ensure proper cell cycle progression. It also impacts pathways related to cell signaling by influencing the turnover of signaling molecules which is important for maintaining cellular homeostasis.