AB203752

Anti-RON (phospho Y1238) antibody

Name: Anti-RON (phospho Y1238) antibody (ab203752) | Abcam
Brand: Abcam Limited
SKU: AB203752
Price: 535 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal RON phospho Y1238 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MST1R phospho Y1238 aa 1200-1300 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

CD136, PTK8, RON, MST1R, Macrophage-stimulating protein receptor, MSP receptor, CDw136, Protein-tyrosine kinase 8, p185-Ron

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RON (phospho Y1238) antibody (AB203752)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RON (phospho Y1238) antibody (AB203752)

Immunohistochemical analysis of formalin-fixed and paraffin embedded rat brain tissue labeling RON (phospho Y1238) using ab203752 at 1/200 dilution, followed by secondary detection and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human MST1R phospho Y1238 aa 1200-1300 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q04912

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>Use at 1/50 - 1/200 with fluorescent detection methods.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Also plays a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

See full target information MST1R phospho Y1238

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular genetics & genomic medicine 8:e1199 PubMed32162843

2020

Systematic analysis of a mitochondrial disease-causing ND6 mutation in mitochondrial deficiency.

Applications

Unspecified application

Species

Unspecified reactive species

Deyu Chen,Qiongya Zhao,Jingting Xiong,Xiaoting Lou,Qinxia Han,Xiujuan Wei,Jie Xie,Xueyun Li,Huaibin Zhou,Lijun Shen,Yanling Yang,Hezhi Fang,Jianxin Lyu

View all publications

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