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AB20036

Anti-Rotavirus antibody

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(3 Publications)

Goat Polyclonal Rotavirus antibody. Suitable for ICC/IF and reacts with Rotavirus samples. Cited in 3 publications. Immunogen corresponding to Virus preparation containing Rotavirus NCDV protein.

View Alternative Names

Major inner capsid protein VP6, NSP4, VP6

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rotavirus

Applications

ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rotavirus": { "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
>95% pure.
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Rotavirus also called RVA is a non-enveloped virus that primarily infects the gastrointestinal tract. It has a double-stranded RNA genome encoding six structural proteins and six non-structural proteins. The virus particles have a triple-layered capsid which is 70-75 nanometers in diameter. Rotavirus is expressed in the small intestine of humans and animals where it attaches to and enters mature enterocytes. The virus disrupts these cells' function and leads to fluid loss and diarrhea.
Biological function summary

Rotavirus significantly impacts intestinal absorption and secretion balance. The virus produces non-structural protein 4 (NSP4) which functions as an enterotoxin. NSP4 alters intracellular calcium homeostasis and induces secretion resulting in diarrhea. Rotavirus is not part of a complex; its independent proteins perform roles that contribute to its pathogenicity and replication.

Pathways

Rotavirus infection affects host signaling pathways like NF-κB and interferon (IFN) responses. Disruption of these pathways helps the virus to circumvent immune elimination and propagate in the host. NSP4 interacts with host extracellular signal-regulated kinases (ERK) influencing cellular processes that give the virus a replication advantage. These pathways signal cellular responses that affect inflammation and cell apoptosis.

Rotavirus is mainly implicated in acute gastroenteritis especially in children under five. This condition can lead to severe dehydration and in extreme cases can be life-threatening without adequate treatment. There is a relation between Rotavirus and the protein β-defensin which the virus counteracts to evade innate immune defenses. Vaccination has proven effective in reducing disease incidence and associated healthcare burdens worldwide.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Rotavirus
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Veterinary research 55:16 PubMed38317245

2024

Use of live attenuated recombinant Newcastle disease virus carrying avian paramyxovirus 2 HN and F protein genes to enhance immune responses against species A rotavirus VP6 protein.

Applications

Unspecified application

Species

Unspecified reactive species

Rofaida Mostafa Soliman,Keisuke Nishioka,Fumi Murakoshi,Takaaki Nakaya

Frontiers in pediatrics 9:731005 PubMed34540774

2021

Whey Protein Lipid Concentrate High in Milk Fat Globule Membrane Components Inhibit Porcine and Human Rotavirus .

Applications

Unspecified application

Species

Unspecified reactive species

Marcia H Monaco,Gabriele Gross,Sharon M Donovan

Science China. Life sciences 54:82-9 PubMed21104033

2010

Immunogenicity and virus-like particle formation of rotavirus capsid proteins produced in transgenic plants.

Applications

WB

Species

Unspecified reactive species

YanMei Yang,Xia Li,Hui Yang,Yuan Qian,You Zhang,RongXiang Fang,XiaoYing Chen
View all publications
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