Anti-RPL19 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

RPL19 also known as 60S ribosomal protein L19 is a component of the 60S subunit of the ribosome. It has a molecular weight of approximately 23 kDa. This protein is ubiquitously expressed in many tissues reflecting its essential role in protein synthesis. As part of the ribosomal structure RPL19 contributes to the assembly and stability of the ribosome aiding in the accurate translation of mRNA into proteins.

Biological function summary

RPL19 functions within the ribosome which is a complex molecular machine responsible for protein synthesis in cells. This protein plays a role in the ribosomal large subunit assembly and stability. RPL19 is part of the ribonucleoprotein complex and interacts with ribosomal RNA and other ribosomal proteins to ensure correct translation process. Maintaining ribosomal structural integrity and function helps in the cells' overall proteome homeostasis.

Pathways

RPL19 is involved in the translation machinery particularly the mRNA translation and protein synthesis pathway. This protein contributes to the ribosomal large subunit in translational machinery which is central to cellular growth and proliferation. It interacts with several ribosomal proteins including RPL5 and RPL11 which are key components in coordinating the synthesis of proteins necessary for various cellular processes. The NMD (nonsense-mediated decay) pathway also governs the regulation of RPL19 ensuring the fidelity and quality control of the protein synthesis.

Associated diseases and disorders

RPL19's dysfunction has implications in ribosomopathies and certain cancers. Aberrations in its expression or function can disrupt normal protein synthesis leading to developmental disorders. Furthermore dysregulation of RPL19 is linked to tumorigenesis notably in disorders involving p53 as the ribosomal proteins interact with MDM2 and influence p53 activity affecting cell cycle regulation and apoptosis. Understanding these connections highlights RPL19's potential as a therapeutic target in related conditions.