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AB234792

Anti-RPL22L1 antibody

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(3 Publications)

Rabbit Polyclonal RPL22L1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human 60S ribosomal protein L22-like 1.

View Alternative Names

Ribosomal protein eL22-like, 60S ribosomal protein L22-like 1, Large ribosomal subunit protein eL22-like 1, RPL22L1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RPL22L1 antibody (AB234792)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RPL22L1 antibody (AB234792)

Paraffin-embedded human kidney tissue stained for RPL22L1 using ab234792 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human 60S ribosomal protein L22-like 1.

Q6P5R6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
>95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RPL22L1 also known as ribosomal protein L22-like 1 acts as a component of the ribosome assembly machinery. It shares similarities with ribosomal protein L22 but harbors distinct functional roles. RPL22L1 has an approximate mass of 15 kDa. Expression of RPL22L1 is extensive in various tissues with significant levels noted in proliferative tissues and certain cancer cell lines. This indicates its role might be pivoted towards cellular growth and replication processes.
Biological function summary

The function of RPL22L1 involves supporting ribosome biogenesis. It participates in the formation of ribonucleoprotein complexes important units for protein synthesis. As part of these complexes RPL22L1 contributes to the stabilization and maturation of ribosomal RNA. Its interaction with other ribosomal proteins fosters assembly of the large ribosomal subunit contributing to efficient translational processes within the cell.

Pathways

The integration of RPL22L1 within cellular mechanisms includes its involvement in translation control and ribosome biogenesis pathways. These pathways are critical for cell growth and proliferation. In conjunction with proteins like RPL5 and RPL11 RPL22L1 helps maintain ribosomal function and integration ensuring efficient protein synthesis. Regulation of those pathways influences overall protein homeostasis impacting cellular health and viability.

Altered RPL22L1 expression links to specific cancers including leukemia and breast cancer. Disruption in RPL22L1's function can lead to aberrant protein synthesis contributing to oncogenic processes. In leukemia changes in expression levels of RPL22L1 and proteins such as RPL10 can shift the balance in ribosome composition affecting cell proliferation rates. Furthermore its association with proliferative tissue further emphasizes its significance in tumor biology and potential as a therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information 60S ribosomal protein L22-like 1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Nature structural & molecular biology 32:2076-2087 PubMed40646309

2025

A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients.

Applications

Unspecified application

Species

Unspecified reactive species

Christopher Nardone,Julian Mintseris,Dingwei He,Justine C Rutter,Benjamin L Ebert,Steven P Gygi,Tom Rapoport

Journal of Cancer 15:2549-2560 PubMed38577587

2024

Ribosomal protein L22 like 1: a promising biomarker for lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yahua Wu,Na Yao,Bin Du,Yingjiao Zhu,Xiaohui Ji,Chengliu Lv,Jinhuo Lai

Nature cell biology 24:1541-1557 PubMed36192632

2022

Alternative RNA splicing modulates ribosomal composition and determines the spatial phenotype of glioblastoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Tatyana D Larionova,Soniya Bastola,Tatiana E Aksinina,Ksenia S Anufrieva,Jia Wang,Victoria O Shender,Dmitriy E Andreev,Tatiana F Kovalenko,Georgij P Arapidi,Polina V Shnaider,Anastasia N Kazakova,Yaroslav A Latyshev,Victor V Tatarskiy,Alexander A Shtil,Pascale Moreau,Francis Giraud,Chaoxi Li,Yichan Wang,Maria P Rubtsova,Olga A Dontsova,Michael Condro,Benjamin M Ellingson,Mikhail I Shakhparonov,Harley I Kornblum,Ichiro Nakano,Marat S Pavlyukov
View all publications
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Product promise

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