Rabbit Polyclonal RPL24 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human 60S ribosomal protein L24 aa 1-150.
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Publications
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- Cell reports 38:1105972022Labeling of heterochronic ribosomes reveals C1ORF109 and SPATA5 control a late step in human ribosome assembly.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChunyang Ni,Daniel A Schmitz,Jeon Lee,Krzysztof Pawłowski,Jun Wu,Michael BuszczakPubMed 35354024
- Nucleic acids research 45:11725-117422017The nuclear mitotic apparatus protein NuMA controls rDNA transcription and mediates the nucleolar stress response in a p53-independent manner.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSwaathi Jayaraman,Shirisha Chittiboyina,Yunfeng Bai,Patricia C Abad,Pierre-Alexandre Vidi,Cynthia V Stauffacher,Sophie A LelièvrePubMed 28981686
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human 60S ribosomal protein L24 aa 1-150. The exact immunogen used to generate this antibody is proprietary information. Database link P83731
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
| Cat | Predicted |
| Cow | Predicted |
| Xenopus laevis | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Cow, Cat, Xenopus laevis | Dilution info - | Notes - |
Target data
Function
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Alternative names
Large ribosomal subunit protein eL24, 60S ribosomal protein L24, 60S ribosomal protein L30, RPL24
Recommended products
Rabbit Polyclonal RPL24 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human 60S ribosomal protein L24 aa 1-150.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human 60S ribosomal protein L24 aa 1-150. The exact immunogen used to generate this antibody is proprietary information. Database link P83731
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
RPL24 also known as Ribosomal Protein L24 functions as part of the 60S large ribosomal subunit. It plays an important role in the structural stability and assembly of ribosomes supporting protein synthesis within the cell. RPL24 has a molecular mass of approximately 17 kDa and exhibits high expression in actively dividing cells like those in the bone marrow and the liver. Its expression is important for the efficient production of ribosomal proteins and cellular growth.
- Biological function summary
The RPL24 protein assists in the translation process by joining with other ribosomal proteins and rRNA components to form the large subunit of the ribosome. It integrates within the ribosome complex ensuring proper alignment of mRNA and tRNA during protein synthesis. RPL24 contributes to the efficiency and accuracy of translating genetic codes into functional proteins which is essential for cellular functioning. It collaborates closely with other ribosomal proteins in translation initiation and elongation processes.
- Pathways
RPL24 plays an integral role in the mTOR signaling pathway which regulates cell growth protein synthesis and metabolism. This pathway heavily relies on functional ribosomes where RPL24 assists in ribosome biogenesis and activity. Another important pathway is the translation initiation pathway where RPL24 works alongside proteins like eIF3 and eIF6 ensuring the proper assembly and function of the ribosome. By participating in these pathways RPL24 supports cellular growth and maintenance.
- Associated diseases and disorders
Improper function or mutation of RPL24 associates with Diamond-Blackfan Anemia a disorder characterized by a failure to produce red blood cells. The disorder links RPL24 to reduced ribosomal function and impaired erythropoiesis. RPL24 also connects to cancers where dysregulation in ribosomal proteins often results in uncontrolled cell growth and proliferation. Mutated ribosomal proteins like those in RPL24 can alter pathways leading to oncogenesis and cancer progression.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-RPL24 antibody (ab126172)
12% SDS PAGE
All lanes: Western blot - Anti-RPL24 antibody (ab126172) at 1/1000 dilution
All lanes: A549 whole cell lysate at 30 µg
Predicted band size: 18 kDa
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