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AB88514

Anti-RPL29 antibody

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(5 Publications)

Mouse Polyclonal RPL29 antibody. Carrier free. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RPL29.

View Alternative Names

Large ribosomal subunit protein eL29, 60S ribosomal protein L29, Cell surface heparin-binding protein HIP, RPL29

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RPL29 antibody (AB88514)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RPL29 antibody (AB88514)

ab88514, at 3 ug/ml, staining RPL29 in formalin-fixed paraffin-embedded Human salivary gland tissue by Immunohistochemistry.

Western blot - Anti-RPL29 antibody (AB88514)
  • WB

Unknown

Western blot - Anti-RPL29 antibody (AB88514)

All lanes:

Western blot - Anti-RPL29 antibody (ab88514) at 1 µg/mL

All lanes:

Human pancreas tissue lysate at 50 µg

Predicted band size: 18 kDa

Observed band size: 18 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human RPL29.

P47914

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RPL29 also known as ribosomal protein L29 is a structural component of the large 60S ribosomal subunit. It has a molecular mass of approximately 17 kDa. This protein contributes to ribosome function by connecting with rRNA and other ribosomal proteins to aid protein synthesis. RPL29 shows strong expression in tissues with high protein turnover such as the liver and pancreas where efficient protein production is necessary for maintaining cellular functions.
Biological function summary

RPL29 takes part in the assembly of the ribosome which is essential for the translation process in protein synthesis. It is not found alone; instead it becomes integrated into the large ribosomal subunit. This integration is critical for the assembly and stability of the ribosomal structure. Without proper RPL29 incorporation ribosome function and consequently cellular protein synthesis can become impaired.

Pathways

The ribosomal protein RPL29 plays important roles in both the translation and ribosome biogenesis pathways. It functions alongside other ribosomal proteins like RPL5 and RPL11 in these pathways to ensure correct assembly and functionality of ribosomes. Ribosome biogenesis is a highly-regulated process that starts in the nucleolus and extends into the cytoplasm involving steps important for cell growth and division.

Mutations or dysregulation in RPL29 have been linked with certain types of cancers such as colorectal carcinoma. Cancerous cells often exhibit altered ribosomal function to support their increased need for protein synthesis. RPL29’s interaction with other ribosomal proteins like RPL11 affects ribosomal stress responses which can impact cancer progression. Additionally aberrations in ribosome function where RPL29 is a player are associated with ribosomopathies a group of disorders characterized by defective ribosome biogenesis and function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the large ribosomal subunit (PubMed : 12962325, PubMed : 23636399, PubMed : 32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed : 12962325, PubMed : 23636399, PubMed : 32669547).
See full target information RPL29
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Cancers 16: PubMed39410048

2024

Honey Targets Ribosome Biogenesis Components to Suppress the Growth of Human Pancreatic Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Aun Ali Bangash,Sahir Sultan Alvi,Muhammad Ali Bangash,Haider Ahsan,Shiza Khan,Rida Shareef,Georgina Villanueva,Divyam Bansal,Mudassier Ahmad,Dae Joon Kim,Subhash C Chauhan,Bilal Bin Hafeez

Aging cell 22:e13954 PubMed37614052

2023

Alterations of lipid-mediated mitophagy result in aging-dependent sensorimotor defects.

Applications

Unspecified application

Species

Unspecified reactive species

Natalia Oleinik,Onder Albayram,Mohamed Faisal Kassir,F Cansu Atilgan,Chase Walton,Eda Karakaya,John Kurtz,Alexander Alekseyenko,Habeeb Alsudani,Megan Sheridan,Zdzislaw M Szulc,Besim Ogretmen

Physical activity and nutrition 27:39-49 PubMed37583071

2023

Effects of aging-induced obesity on the transcriptional expression of adipogenesis and thermogenic activity in the gonadal white adipose, brown adipose, and skeletal muscle tissues.

Applications

Unspecified application

Species

Unspecified reactive species

Insu Kwon,Nurul Fatihah Talib,JunShu Zhu,Hyung-In Yang,Kyoung Soo Kim

Nucleic acids research 50:2872-2888 PubMed35150276

2022

Genome-wide RNAi screen identifies novel players in human 60S subunit biogenesis including key enzymes of polyamine metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Kerstin Dörner,Lukas Badertscher,Bianka Horváth,Réka Hollandi,Csaba Molnár,Tobias Fuhrer,Roger Meier,Marie Sárazová,Jasmin van den Heuvel,Nicola Zamboni,Peter Horvath,Ulrike Kutay

Science advances 5:eaax1978 PubMed31535025

2019

Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress.

Applications

Unspecified application

Species

Unspecified reactive species

Natalia Oleinik,Jisun Kim,Braden M Roth,Shanmugam Panneer Selvam,Monika Gooz,Roger H Johnson,John J Lemasters,Besim Ogretmen
View all publications
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Product promise

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