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AB74740

Anti-RPL39 antibody

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(3 Publications)

Rabbit Polyclonal RPL39 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications.

View Alternative Names

Large ribosomal subunit protein eL39, 60S ribosomal protein L39, RPL39

1 Images
Western blot - Anti-RPL39 antibody (AB74740)
  • WB

Unknown

Western blot - Anti-RPL39 antibody (AB74740)

All lanes:

Western blot - Anti-RPL39 antibody (ab74740) at 1/500 dilution

Lane 1:

HepG2 cell extracts at 30 µg

Lane 2:

COLO cell extracts at 30 µg

Lane 3:

COLO cell extracts at 30 µg with immunising peptide

Predicted band size: 7 kDa

Observed band size: 7 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab74740 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RPL39 also known as Ribosomal Protein L39 is a component of the ribosome the cell's protein synthesis machinery. It has a small molecular mass of around 6 kilodaltons. This protein is ubiquitously expressed in many tissues indicating its importance in cellular function. As part of the ribosomal subunits RPL39 plays a mechanical role in facilitating mRNA translation by ensuring the proper assembly and function of the ribosome.
Biological function summary

RPL39 contributes significantly to the protein synthesis process. It forms part of the large 60S subunit of the ribosome which requires it for effective translation and expansion of the polypeptide chain. In the ribosomal complex RPL39 supports the stability and proper function of the ribosome enabling proper decoding of genetic information. Its interaction with other ribosomal proteins ensures the continual and efficient production of proteins needed for basic cellular processes.

Pathways

The role of RPL39 is essential in the translation pathway a core part of the central dogma of molecular biology. Within this pathway RPL39 interacts with other ribosomal proteins such as RPL10 and RPL5 to facilitate the synthesis of proteins. Additionally it associates with the mTOR signaling pathway influencing cell growth and protein synthesis regulation and works closely with mTOR complex proteins like Raptor to modulate the rate of translation in response to various stimuli.

RPL39 has notable implications in cancer and embryonic development anomalies. Abnormal expression of RPL39 has been linked to the progression of certain cancers such as lung and breast cancers. This connection often involves interactions with c-Myc a protein whose dysregulation is common in several cancer types further intensifying tumor growth and progression. Additionally mutations in RPL39 have been associated with Diamond-Blackfan Anemia a disorder characterized by faulty ribosome function revealing its important role in maintaining proper blood cell production through its interaction with other ribosomal proteins.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

RNA-binding component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
See full target information RPL39
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Canadian respiratory journal 2025:7139235 PubMed39957991

2025

RPL39 Was Associated With Sex Differences in Pulmonary Arterial Hypertension.

Applications

Unspecified application

Species

Unspecified reactive species

Haixia Wang,Ling Li,Guangyuan Zhou,Lu Wang,Zeang Wu

Cell reports 29:3605-3619.e10 PubMed31825839

2019

On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons.

Applications

Unspecified application

Species

Unspecified reactive species

Toshiaki Shigeoka,Max Koppers,Hovy Ho-Wai Wong,Julie Qiaojin Lin,Roberta Cagnetta,Asha Dwivedy,Janaina de Freitas Nascimento,Francesca W van Tartwijk,Florian Ströhl,Jean-Michel Cioni,Julia Schaeffer,Mark Carrington,Clemens F Kaminski,Hosung Jung,William A Harris,Christine E Holt

Proceedings of the National Academy of Sciences of 111:8838-43 PubMed24876273

2014

Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling.

Applications

Unspecified application

Species

Human

Bhuvanesh Dave,Sergio Granados-Principal,Rui Zhu,Stephen Benz,Shahrooz Rabizadeh,Patrick Soon-Shiong,Ke-Da Yu,Zhimin Shao,Xiaoxian Li,Michael Gilcrease,Zhao Lai,Yidong Chen,Tim H-M Huang,Haifa Shen,Xuewu Liu,Mauro Ferrari,Ming Zhan,Stephen T C Wong,Muthiah Kumaraswami,Vivek Mittal,Xi Chen,Steven S Gross,Jenny C Chang
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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