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AB241509

Anti-RPL6 antibody

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(1 Publication)

Rabbit Polyclonal RPL6 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RPL6 aa 100-200.

View Alternative Names

TXREB1, RPL6, Large ribosomal subunit protein eL6, 60S ribosomal protein L6, Neoplasm-related protein C140, Tax-responsive enhancer element-binding protein 107, TaxREB107

1 Images
Western blot - Anti-RPL6 antibody (AB241509)
  • WB

Supplier Data

Western blot - Anti-RPL6 antibody (AB241509)

All lanes:

Western blot - Anti-RPL6 antibody (ab241509) at 0.04 µg/mL

Lane 1:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 50 µg

Lane 2:

HEK-293T whole cell lysate at 15 µg

Lane 3:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 50 µg

Lane 4:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate at 50 µg

Predicted band size: 33 kDa

false

Exposure time: 30s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human RPL6 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q02878

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RPL6 also known as Ribosomal Protein L6 is an important component of the 60S ribosomal subunit. It weighs approximately 28 kilodaltons and is found primarily in the cytoplasm where the ribosomal subunit assembly takes place. RPL6 is expressed in various human tissues including liver heart and skeletal muscle. This protein plays a fundamental role in protein synthesis by facilitating the translation process and contributing to the structural integrity of ribosomes.
Biological function summary

The function of RPL6 is critical for ribosome stability and efficient protein synthesis. As part of the 60S ribosomal subunit it associates with other ribosomal proteins and rRNA to form a functional ribosome. This relationship enables proper alignment of mRNA and tRNAs during translation ensuring that amino acids are added correctly according to the genetic code. Abnormalities in RPL6 can disrupt this process leading to defects in protein synthesis.

Pathways

The role of RPL6 in translation becomes evident through its involvement in the mTOR signaling pathway. This pathway regulates cell growth proliferation and survival by modulating ribosome biogenesis and protein synthesis. RPL6 interacts with other ribosomal proteins such as RPS6 in this pathway to promote efficient translation and cellular response to growth signals. In addition the function of RPL6 in the p53 signaling pathway highlights its importance in cell cycle control and stress response.

Mutations or deregulation of RPL6 have been linked to cancers and Diamond-Blackfan anemia. In cancer alterations in RPL6 expression correlate with changes in cell proliferation rates and impact tumor growth. Associations with proteins like MYC which is involved in cell cycle regulation further connect RPL6 to oncogenic processes. In Diamond-Blackfan anemia a disorder characterized by defective erythropoiesis disruptions in ribosomal protein function such as that of RPL6 contribute to the disease pathology pointing to a broader role in hematopoiesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the large ribosomal subunit (PubMed : 12962325, PubMed : 23636399, PubMed : 25901680, PubMed : 25957688, PubMed : 32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed : 12962325, PubMed : 23636399, PubMed : 25901680, PubMed : 25957688, PubMed : 32669547).. (Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I (PubMed : 8457378).
See full target information RPL6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Histology and histopathology 40:733-743 PubMed39380528

2024

Mechanism of KMT2D-mediated epigenetic modification in IL-1β-induced nucleus pulposus cell degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Hongjiang Liu,Haiquan Liu,Zuyu Meng,Wensheng Zhang
View all publications
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Product promise

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