Mouse Polyclonal RPLP0 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human 60S acidic ribosomal protein P0.
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Publications
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- eLife 7:2018Efficient analysis of mammalian polysomes in cells and tissues using Ribo Mega-SEC.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHarunori Yoshikawa et. al.PubMed 30095066
- Nature communications 7:121562016ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer.
- PloS one 9:e914652014Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin.
- Proceedings of the National Academy of Sciences of 110:17975-802013Loss of estrogen-related receptor α promotes hepatocarcinogenesis development via metabolic and inflammatory disturbances.
- PloS one 5:e118292010HSV usurps eukaryotic initiation factor 3 subunit M for viral protein translation: novel prevention target.
Key facts
- Isotype
- IgG
- Host species
- Mouse
- Storage buffer
pH: 7.4
Constituents: 100% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Full Length Protein corresponding to Human 60S acidic ribosomal protein P0. Database link P05388
Reactivity data
Select an application| WB | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1 µg/mL | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 10 µg/mL | Notes - |
Associated Products
Select an associated product type
5 products for Alternative Product
Target data
Function
Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
Alternative names
Large ribosomal subunit protein uL10, 60S acidic ribosomal protein P0, 60S ribosomal protein L10E, RPLP0
Recommended products
Mouse Polyclonal RPLP0 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human 60S acidic ribosomal protein P0.
Key facts
- Isotype
- IgG
- Host species
- Mouse
- Storage buffer
pH: 7.4
Constituents: 100% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Human 60S acidic ribosomal protein P0. Database link P05388
- Carrier free
- Yes
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
RPLP0 also known as 60S acidic ribosomal protein P0 is an integral component of the ribosomal machinery. It acts as a scaffold within the large 60S subunit of the ribosome which plays a fundamental role in protein synthesis. The protein has an approximate mass of 34.4 kDa. RPLP0 is ubiquitously expressed across various tissues indicating its essential role in cellular biology. Its expression is well-documented in highly proliferative tissues and organs reflecting the ribosome's central role in maintaining cellular growth and division.
- Biological function summary
RPLP0 participates actively in ribosome structure and function. It forms part of the ribosomal stalk together with the P1 and P2 proteins facilitating interactions with GTPase translation factors during protein synthesis. This ribosomal complex is important for elongation phase of protein translation where it actively assists in the accurate and efficient elongation of polypeptide chains. By participating in the ribosome's structural framework RPLP0 drives the translation process influencing protein output in cells. This makes it essential for overall protein homeostasis.
- Pathways
RPLP0 is deeply embedded within the processes of translation and ribosome biogenesis. It associates with the major pathway of ribosome assembly wherein new ribosomes are synthesized and configured. It functions alongside other ribosomal proteins like RPLP1 and RPLP2 which work together to maintain efficient protein synthesis. The interaction among these proteins within the translation pathway highlights the integrated nature of RPLP0 in facilitating cellular protein production.
- Associated diseases and disorders
RPLP0 has notable implications in cancer and Diamond-Blackfan anemia (DBA). Aberrations in ribosomal proteins including RPLP0 have been linked to oncogenesis where disrupted protein synthesis contributes to uncontrolled cellular proliferation. Additionally alterations in RPLP0 have associations with DBA a ribosomopathy characterized by defective red blood cell production. Within these disease contexts RPLP0's interaction with other ribosomal proteins like RPL11 can influence disease progression and cellular anomalies seen in such conditions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Western blot - Anti-RPLP0 antibody (ab88872)
All lanes: Western blot - Anti-RPLP0 antibody (ab88872) at 1 µg/mL
All lanes: Jurkat cell lysate at 50 µg
Predicted band size: 34 kDa
Observed band size: 34 kDa
Western blot - Anti-RPLP0 antibody (ab88872)
All lanes: Western blot - Anti-RPLP0 antibody (ab88872) at 1 µg/mL
Lane 1: RPLP0 transfected 293T cell lysate at 25 µg
Lane 2: Non-transfected lysate at 25 µg
Predicted band size: 34 kDa
Observed band size: 34 kDa
Immunocytochemistry/ Immunofluorescence - Anti-RPLP0 antibody (ab88872)
ab88872 at 10μg/ml staining RPLP0 in HeLa cells by Immunofluorescence.
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