Anti-RPRD2 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

RPRD2 also known as Regulation of Nuclear Pre-mRNA Domain-Containing Protein 2 is involved in transcription regulation. It has a molecular weight of approximately 70 kDa and is expressed in various tissues with higher levels found in the liver and kidney. Mechanically RPRD2 interacts with the carboxyl-terminal domain of RNA polymerase II acting as a transcriptional regulator by facilitating the dephosphorylation process. This interaction influences the transcription cycle highlighting its role in gene expression regulation.

Biological function summary

The regulatory activities of RPRD2 impact cellular processes through its part in multiple protein complexes particularly those focusing on transcription and RNA processing. RPRD2 collaborates with other proteins such as RPRD1A and RPRD1B to form a complex involved in mediating interactions with transcription factors and phosphatases. This complex functions in a coordinated manner to regulate the transcription machinery and contribute to RNA polymerase II activity modulation which in turn affects gene expression at a broader level.

Pathways

RPRD2 participates in several critical pathways including the RNA polymerase II transcription pathway and the mRNA maturation pathway. RPRD2's connection with the phosphatase complex places it in a network of interactions vital to maintaining transcriptional fidelity. Additionally RPRD2 is related to pathways involving proteins such as CDK9 which plays a role in controlling pause release at transcription start sites. These interactions position RPRD2 as an essential mediator within transcriptional networks.

Associated diseases and disorders

RPRD2 has connections to cancer and neurodegenerative disorders. Its role in transcription regulation links it to tumor development with dysregulation potentially contributing to oncogenesis. Additionally the interaction with proteins like RNA polymerase II associates RPRD2 with neurodegenerative diseases where transcriptional dysregulation often plays a significant role. These connections highlight RPRD2 as a significant target for further research in understanding complex diseases.