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AB220708

Anti-RPS18 antibody

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(1 Publication)

Rabbit Polyclonal RPS18 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RPS18 aa 50-150.

View Alternative Names

D6S218E, RPS18, Small ribosomal subunit protein uS13, 40S ribosomal protein S18, Ke-3, Ke3

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-RPS18 antibody (AB220708)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-RPS18 antibody (AB220708)

Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized SK-MEL-30 cells labeling RPS18 with ab220708 at 4 μg/ml (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human RPS18 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

P62269

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Dog": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Goat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Pig": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Zebrafish": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RPS18 also known as the Ribosomal Protein S18 is a component of the small 40S subunit of ribosomes. This protein is composed of 157 amino acids and its mass is approximately 17.5 kDa. RPS18 is ubiquitously expressed in many tissues and plays an essential role in the translation process by facilitating the assembly and structural stability of the ribosome. Due to its universal presence it serves as a marker for protein synthesis activity in various cellular contexts.
Biological function summary

RPS18 is involved in the production of proteins by participating in the mRNA translation process. As part of the ribosomal small subunit complex it interacts with ribosomal RNA (rRNA) and other ribosomal proteins to enable accurate decoding of mRNA sequences into polypeptides. This decoding is necessary for cellular growth and division making RPS18 indispensable for cell proliferation and maintenance.

Pathways

RPS18 is integrated into translational machinery and contributes directly to the mRNA translation pathway. This process is important for the synthesis of all proteins within a cell linking RPS18 to other translation-related proteins such as eukaryotic initiation factor 3 (eIF3). RPS18 also connects to the ribosome biogenesis pathway which is important for the assembly and upkeep of ribosomes ensuring efficient cellular function.

Aberrations in RPS18 expression or function have been associated with certain types of cancer such as colorectal cancer. Altered levels of RPS18 may influence cellular proliferation possibly in connection with dysregulated pathways involving proteins like beta-catenin known to be implicated in cancer progression. Additionally variations in RPS18 expression patterns have been linked to Diamond-Blackfan Anemia a disorder characterized by defective ribosome production and function. In this condition RPS18 alterations may impact the ribosomal protein networks including those involving RPS19 which is another protein related to the disease.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
See full target information RPS18
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Autophagy 21:530-547 PubMed39324484

2024

SMURF1 mediates damaged lysosomal homeostasis by ubiquitinating PPP3CB to promote the activation of TFEB.

Applications

Unspecified application

Species

Unspecified reactive species

Qin Xia,Xuan Liu,Lu Zhong,Jun Qu,Lei Dong
View all publications
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Product promise

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