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AB201091

Anti-RPS19BP1/AROS antibody

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(4 Publications)

Rabbit Polyclonal RPS19BP1/AROS antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human RPS19BP1 aa 50 to C-terminus.

View Alternative Names

AROS, RPS19BP1, Active regulator of SIRT1, 40S ribosomal protein S19-binding protein 1, RPS19-binding protein 1, S19BP

1 Images
Western blot - Anti-RPS19BP1/AROS antibody (AB201091)
  • WB

Supplier Data

Western blot - Anti-RPS19BP1/AROS antibody (AB201091)

All lanes:

Western blot - Anti-RPS19BP1/AROS antibody (ab201091)

Lane 1:

HEK293T whole cell lysate

Lane 2:

RAW264.7 whole cell lysate

Lane 3:

H9C2 whole cell lysate

Predicted band size: 15 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human RPS19BP1 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q86WX3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab201091 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity of is > 95% (by SDS-PAGE).
Storage buffer
pH: 7.3 Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RPS19BP1 also known as AROS (Active Regulator Of SIRT1) is a protein with a molecular weight of approximately 14 kDa. It plays an important role in cellular processes. The protein is known to enhance the deacetylase activity of SIRT1 a member of the sirtuin family involved in longevity and metabolism regulation. RPS19BP1/AROS resides mainly in the nucleus and is ubiquitously expressed in various human tissues indicating its broad role in cellular function.
Biological function summary

RPS19BP1/AROS interacts with SIRT1 to modulate deacetylation of target proteins. SIRT1 is an important regulator in various processes such as aging inflammation and cellular stress responses. RPS19BP1 contributes to these processes by activating SIRT1 forming an association to influence cellular outcomes. The interaction between RPS19BP1 and SIRT1 helps in regulating acetylation of non-histone proteins which impacts gene expression and cell survival mechanisms.

Pathways

RPS19BP1/AROS affects cellular pathways including the SIRT1 and AMPK pathways. The SIRT1 pathway is integral to energy balance and stress response and RPS19BP1 modulates this pathway by enhancing SIRT1 activity influencing gluconeogenesis and mitochondrial biogenesis. AMPK is another pathway where RPS19BP1 indirectly plays a role with AMPK known for its role in energy homeostasis. RPS19BP1/AROS through its action on SIRT1 impacts AMPK-related processes thereby linking it to cellular energy regulation and metabolic responses.

RPS19BP1/AROS holds relevance in the context of cancer and metabolic diseases. Enhanced SIRT1 activity through RPS19BP1 association can influence cancer cell survival and proliferation marking it as a potential target for cancer therapies. Additionally metabolic disorders like type 2 diabetes have associations with the dysregulation of pathways involving RPS19BP1 and SIRT1. The interaction with proteins such as p53 which is involved in cell cycle control further illustrates its role in tumorigenesis and metabolic processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Acts as a chaperone that specifically mediates the integration of RPS19 in state post-A1 (PubMed : 34516797). Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (PubMed : 17964266).
See full target information RPS19BP1
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Experimental & molecular medicine 55:1232-1246 PubMed37258580

2023

SIRT1 ubiquitination is regulated by opposing activities of APC/C-Cdh1 and AROS during stress-induced premature senescence.

Applications

Unspecified application

Species

Unspecified reactive species

Sang Hyup Lee,Ji-Hye Yang,Ui-Hyun Park,Hanbyeul Choi,Yoo Sung Kim,Bo-Eun Yoon,Hye-Jeong Han,Hyun-Taek Kim,Soo-Jong Um,Eun-Joo Kim

PeerJ 11:e15232 PubMed37180577

2023

LINC00106/RPS19BP1/p53 axis promotes the proliferation and migration of human prostate cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Lingxiang Lu,Zhen Tian,Jicheng Lu,Minjun Jiang,Jianchun Chen,Shuai Guo,Yuhua Huang

Phytomedicine : international journal of phytother 77:153275 PubMed32659678

2020

Material basis, effect, and mechanism of ethanol extract of Pinellia ternata tubers on oxidative stress-induced cell senescence.

Applications

Unspecified application

Species

Unspecified reactive species

Ding Tang,Renyi Yan,Yuan Sun,Guoyin Kai,Keli Chen,Juan Li

Oncotarget 8:65717-65729 PubMed29029466

2017

A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction.

Applications

Unspecified application

Species

Unspecified reactive species

Juan Li,Chun-Xia Zhang,Yi-Mei Liu,Ke-Li Chen,Gang Chen
View all publications
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