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AB236598

Anti-RPS19BP1/AROS antibody

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(2 Publications)

Rabbit Polyclonal RPS19BP1/AROS antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RPS19BP1.

View Alternative Names

AROS, RPS19BP1, Active regulator of SIRT1, 40S ribosomal protein S19-binding protein 1, RPS19-binding protein 1, S19BP

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RPS19BP1/AROS antibody (AB236598)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RPS19BP1/AROS antibody (AB236598)

Paraffin-embedded human colon cancer tissue stained for RPS19BP1/AROS using ab236598 at 1/50 dilution in immunohistochemical analysis.

Western blot - Anti-RPS19BP1/AROS antibody (AB236598)
  • WB

Supplier Data

Western blot - Anti-RPS19BP1/AROS antibody (AB236598)

All lanes:

Western blot - Anti-RPS19BP1/AROS antibody (ab236598) at 1/1000 dilution

Lane 1:

EC109 whole cell lysate

Lane 2:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/15000 dilution

Predicted band size: 15 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human RPS19BP1.

Q86WX3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RPS19BP1 also known as AROS (Active Regulator Of SIRT1) is a protein with a molecular weight of approximately 14 kDa. It plays an important role in cellular processes. The protein is known to enhance the deacetylase activity of SIRT1 a member of the sirtuin family involved in longevity and metabolism regulation. RPS19BP1/AROS resides mainly in the nucleus and is ubiquitously expressed in various human tissues indicating its broad role in cellular function.
Biological function summary

RPS19BP1/AROS interacts with SIRT1 to modulate deacetylation of target proteins. SIRT1 is an important regulator in various processes such as aging inflammation and cellular stress responses. RPS19BP1 contributes to these processes by activating SIRT1 forming an association to influence cellular outcomes. The interaction between RPS19BP1 and SIRT1 helps in regulating acetylation of non-histone proteins which impacts gene expression and cell survival mechanisms.

Pathways

RPS19BP1/AROS affects cellular pathways including the SIRT1 and AMPK pathways. The SIRT1 pathway is integral to energy balance and stress response and RPS19BP1 modulates this pathway by enhancing SIRT1 activity influencing gluconeogenesis and mitochondrial biogenesis. AMPK is another pathway where RPS19BP1 indirectly plays a role with AMPK known for its role in energy homeostasis. RPS19BP1/AROS through its action on SIRT1 impacts AMPK-related processes thereby linking it to cellular energy regulation and metabolic responses.

RPS19BP1/AROS holds relevance in the context of cancer and metabolic diseases. Enhanced SIRT1 activity through RPS19BP1 association can influence cancer cell survival and proliferation marking it as a potential target for cancer therapies. Additionally metabolic disorders like type 2 diabetes have associations with the dysregulation of pathways involving RPS19BP1 and SIRT1. The interaction with proteins such as p53 which is involved in cell cycle control further illustrates its role in tumorigenesis and metabolic processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Acts as a chaperone that specifically mediates the integration of RPS19 in state post-A1 (PubMed : 34516797). Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (PubMed : 17964266).
See full target information RPS19BP1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Translational lung cancer research 14:1351-1370 PubMed40386722

2025

was stabilized through N-methyladenosine methylation and exerted its anticancer effects in lung squamous cell carcinoma by inhibiting SIRT1 activity via CCAR2.

Applications

Unspecified application

Species

Unspecified reactive species

Qihang Yan,Wingshing Wong,Jinsong Lei,Dachuan Liang,Jie Yang,Li Gong,Rossana Berardi,Shuqin Dai,Junye Wang

iScience 26:106603 PubMed37128611

2023

Gαs slow conformational transition upon GTP binding and a novel Gαs regulator.

Applications

Unspecified application

Species

Unspecified reactive species

Donghoon Ahn,Davide Provasi,Nguyen Minh Duc,Jun Xu,Leslie Salas-Estrada,Aleksandar Spasic,Min Woo Yun,Juyeong Kang,Dongmin Gim,Jaecheol Lee,Yang Du,Marta Filizola,Ka Young Chung
View all publications
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Product promise

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