Anti-RRAGC antibody

Target data

Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed : 20381137, PubMed : 24095279, PubMed : 27234373, PubMed : 31601708, PubMed : 31601764, PubMed : 32612235, PubMed : 34071043, PubMed : 36697823, PubMed : 37057673). Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form : RagC/RRAGC is in its active form when GDP-bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) (PubMed : 24095279, PubMed : 31601708, PubMed : 31601764, PubMed : 32868926). In its GDP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed : 20381137, PubMed : 24095279, PubMed : 27234373, PubMed : 32612235, PubMed : 36697823). This is a crucial step in the activation of the MTOR signaling cascade by amino acids (PubMed : 20381137, PubMed : 24095279, PubMed : 27234373). Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3 : GDP-bound RagC/RRAGC mediates recruitment of MiT/TFE factors TFEB and TFE3 (PubMed : 32612235, PubMed : 36697823).