Rabbit Polyclonal RREB1 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RREB1 aa 1350-1450.
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- Molecular therapy. Nucleic acids 26:787-7972021lncRNA MELTF-AS1 facilitates osteosarcoma metastasis by modulating MMP14 expression.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLei Ding,Taiyuan Liu,Yuan Qu,Zhichen Kang,Lixin Guo,Haina Zhang,Junjie Jiang,Fuling Qu,Wanbao Ge,Shanyong ZhangPubMed 34729248
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7 - 8
Preservative: 0.09% Sodium azide
Constituents: 99% Tris citrate/phosphate- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human RREB1 aa 1350-1450. The exact immunogen used to generate this antibody is proprietary information. Database link Q92766
Reactivity data
Select an application| IP | |
|---|---|
| Human | Tested |
| Chimpanzee | Predicted |
| Gorilla | Predicted |
| Rhesus monkey | Predicted |
IP
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 2.00000-10.00000 µg/mg of lysate | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Chimpanzee, Rhesus monkey, Gorilla | Dilution info - | Notes - |
Associated Products
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Target data
Function
Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445).
Alternative names
FINB, RREB1, Ras-responsive element-binding protein 1, RREB-1, Finger protein in nuclear bodies, Raf-responsive zinc finger protein LZ321, Zinc finger motif enhancer-binding protein 1, Zep-1
Recommended products
Rabbit Polyclonal RREB1 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RREB1 aa 1350-1450.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7 - 8
Preservative: 0.09% Sodium azide
Constituents: 99% Tris citrate/phosphate- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human RREB1 aa 1350-1450. The exact immunogen used to generate this antibody is proprietary information. Database link Q92766
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
RREB1 also known as Ras-responsive element-binding protein 1 is a zinc finger transcription factor with a molecular mass of approximately 197 kDa. RREB1 is highly expressed in various tissues including the pancreas lung and prostate. Its primary role involves binding to specific Ras-responsive elements (RREs) in the DNA regulating the transcription of genes that are pivotal for cell differentiation growth and apoptosis.
- Biological function summary
The RREB1 protein interacts with other components to activate or repress target gene expression often acting as part of larger transcriptional complexes. It influences key biological processes such as embryonic development and cellular response to stress by controlling genes involved in these pathways. The interconnected function of RREB1 guides essential cellular decisions including how cells adapt to signaling cues in their environment.
- Pathways
RREB1 significantly contributes to the Ras signaling pathway and the MAPK/ERK pathway connecting it to important cellular events like proliferation and differentiation. RREB1 functions alongside proteins such as RAS and MEK collaborating to transmit signals from the cell surface to the nucleus. Through these pathways RREB1 plays a role in adjusting cellular responses to external stimuli influencing gene expression patterns critical for diverse cell functions.
- Associated diseases and disorders
The dysregulation of RREB1 has connections to cancer including prostate and pancreatic cancers. Abnormal RREB1 function can lead to uncontrolled cell proliferation due to its role in gene expression regulation. It has interactions with proteins such as KRAS in these disorders contributing to oncogenic transformations. Additionally alterations in RREB1 are linked to diabetes mellitus where its misregulation might affect insulin signaling pathways impacting glucose metabolism and homeostasis.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunoprecipitation - Anti-RREB1 antibody (ab113287)
Detection of RREB1 in Immunoprecipitates of HeLa whole cell lysate (1 mg for IP, 20% of IP loaded) using ab113287 at 6 µg/mg lysate for IP. A Rabbit anti-RREB1 antibody which recognizes a downstream epitope was used at 1 μg/ml for subsequent Western blot detection. Lane 2 represents control IgG IP. Detection: Chemiluminescence with an exposure time of 30 seconds.
All lanes: Immunoprecipitation - Anti-RREB1 antibody (ab113287)
Predicted band size: 181 kDa
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