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AB64168

Anti-RREB1 antibody

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(5 Publications)

Rabbit Polyclonal RREB1 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Ras-responsive element-binding protein 1.

View Alternative Names

Ras-responsive element-binding protein 1, RREB-1, RAS-responsive zinc finger transcription factor RREB, Rreb1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RREB1 antibody (AB64168)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RREB1 antibody (AB64168)

ab64168 at 10μg/ml staining RREB1 in mouse kidney by Immunohistochemistry, Formalin-fixed, paraffin-embedded tissue.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Mouse Ras-responsive element-binding protein 1.

Q3UH06

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 Preservative: 0.01% Sodium azide Constituents: 0.87% Sodium chloride, 0.42% Tripotassium orthophosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RREB1 also known as Ras-responsive element-binding protein 1 is a zinc finger transcription factor with a molecular mass of approximately 197 kDa. RREB1 is highly expressed in various tissues including the pancreas lung and prostate. Its primary role involves binding to specific Ras-responsive elements (RREs) in the DNA regulating the transcription of genes that are pivotal for cell differentiation growth and apoptosis.
Biological function summary

The RREB1 protein interacts with other components to activate or repress target gene expression often acting as part of larger transcriptional complexes. It influences key biological processes such as embryonic development and cellular response to stress by controlling genes involved in these pathways. The interconnected function of RREB1 guides essential cellular decisions including how cells adapt to signaling cues in their environment.

Pathways

RREB1 significantly contributes to the Ras signaling pathway and the MAPK/ERK pathway connecting it to important cellular events like proliferation and differentiation. RREB1 functions alongside proteins such as RAS and MEK collaborating to transmit signals from the cell surface to the nucleus. Through these pathways RREB1 plays a role in adjusting cellular responses to external stimuli influencing gene expression patterns critical for diverse cell functions.

The dysregulation of RREB1 has connections to cancer including prostate and pancreatic cancers. Abnormal RREB1 function can lead to uncontrolled cell proliferation due to its role in gene expression regulation. It has interactions with proteins such as KRAS in these disorders contributing to oncogenic transformations. Additionally alterations in RREB1 are linked to diabetes mellitus where its misregulation might affect insulin signaling pathways impacting glucose metabolism and homeostasis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed : 12700664). Represses the angiotensinogen gene (By similarity). Negatively regulates the transcriptional activity of AR (By similarity). Potentiates the transcriptional activity of NEUROD1 (By similarity). Binds specifically to the allelic variant of the CDKN2A promoter present in Balb/c mice, which leads to a down-regulation of CDKN2A expression in this strain, and, as a consequence, to an elevated susceptibility to pristane-induced tumors (PubMed : 12700664). Promotes brown adipocyte differentiation (PubMed : 27923061). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (By similarity).
See full target information Ras-responsive element-binding protein 1
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Journal of experimental & clinical cancer research : CR 42:209 PubMed37596700

2023

LncRNA SNHG4 promotes prostate cancer cell survival and resistance to enzalutamide through a let-7a/RREB1 positive feedback loop and a ceRNA network.

Applications

Unspecified application

Species

Unspecified reactive species

Qingzhuo Dong,Hui Qiu,Chiyuan Piao,Zhengxiu Li,Xiaolu Cui

Frontiers in oncology 10:316 PubMed32266133

2020

Promoter-Level Transcriptome Identifies Stemness Associated With Relatively High Proliferation in Pancreatic Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ru Chen,Aiko Sugiyama,Naoyuki Kataoka,Masahiro Sugimoto,Shoko Yokoyama,Akihisa Fukuda,Shigeo Takaishi,Hiroshi Seno

Experimental and therapeutic medicine 12:4121-4127 PubMed28105140

2016

Role of miR-145 in chronic constriction injury in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaolin Pang,Yuanzhang Tang,Dongya Zhang

Oncogene 32:2576-85 PubMed22751122

2012

RREB1 repressed miR-143/145 modulates KRAS signaling through downregulation of multiple targets.

Applications

Unspecified application

Species

Unspecified reactive species

O A Kent,K Fox-Talbot,M K Halushka

Molecular cancer therapeutics 10:1470-80 PubMed21622730

2011

Restitution of tumor suppressor microRNAs using a systemic nanovector inhibits pancreatic cancer growth in mice.

Applications

IHC-P

Species

Mouse

Dipankar Pramanik,Nathaniel R Campbell,Collins Karikari,Raghu Chivukula,Oliver A Kent,Joshua T Mendell,Anirban Maitra
View all publications
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