Anti-RRN3 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

RRN3 is involved in the regulation of ribosome production. It acts as a mediator between the RNA polymerase I complex and the transcription machinery ensuring accurate transcription initiation of rRNA. This interaction forms part of a larger complex that includes the upstream binding factor (UBF) which stabilizes the pre-initiation complex promoting efficient rRNA transcription. RRN3 is important for the maintenance of cellular metabolic activity and overall protein synthesis levels.

Pathways

RRN3 is integral to nutrient signaling and cell growth regulation. It participates in the mechanistic target of rapamycin (mTOR) pathway which controls cell growth and proliferation in response to nutrient availability. RRN3 interacts with mTORC1 to link nutrient signals to ribosome production modulating cellular growth rates. Furthermore RRN3 is associated with the ribosomal biogenesis stress response pathway engaging proteins such as S6 kinase which is activated under conditions requiring increased protein synthesis.