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AB121832

Anti-RRP15 antibody

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(2 Publications)

Rabbit Polyclonal RRP15 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RRP15 aa 1-100.

View Alternative Names

KIAA0507, CGI-115, RRP15, RRP15-like protein, Ribosomal RNA-processing protein 15

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RRP15 antibody (AB121832)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RRP15 antibody (AB121832)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney tissue labelling RRP15 with ab121832 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RRP15 antibody (AB121832)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RRP15 antibody (AB121832)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human duodenum tissue labelling RRP15 with ab121832 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RRP15 antibody (AB121832)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RRP15 antibody (AB121832)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human endometrium tissue labelling RRP15 with ab121832 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RRP15 antibody (AB121832)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RRP15 antibody (AB121832)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human cerebral cortex tissue labelling RRP15 with ab121832 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunocytochemistry/ Immunofluorescence - Anti-RRP15 antibody (AB121832)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-RRP15 antibody (AB121832)

Immunocytochemistry analysis of U-2 OS (human bone osteosarcoma epithelial cell line) cells labelling RRP15 with ab121832 at 2 μg/mL.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human RRP15 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q9Y3B9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RRP15 also known as Ribosomal RNA Processing 15 Homolog is a protein involved in ribosome biogenesis. It has a molecular mass of approximately 27 kDa. This protein is present mainly in the nucleolus a substructure of the nucleus in eukaryotic cells. RRP15 participates mechanically in the processing and maturation of ribosomal RNA (rRNA) essential for forming effective ribosomes. By interacting with other proteins and rRNA it plays a direct role in the assembly of the ribosomal subunit.
Biological function summary

RRP15 is part of a large ribonucleoprotein complex involved in the pre-rRNA processing within the nucleolus. It acts as a factor in the ribosome assembly line influencing the synthesis and maturation of the 60S ribosomal subunit. By coordinating with other ribosome biogenesis proteins RRP15 ensures proper ribosomal function which is necessary for protein synthesis. Its interactions are critical in maintaining the pace and accuracy of ribosome assembly assisting in cellular growth and proliferation.

Pathways

RRP15 is integral to the ribosome biogenesis pathway and is related to the cell growth and division pathways. It interacts with other ribosomal assembly proteins such as Nop16 and Noc2 to facilitate correct formation of ribosomal subunits. The protein’s activity connects with the RNA transcription and processing influencing not just ribosome assembly but also the overall efficiency of protein translation. RRP15's function in these pathways highlights its importance in maintaining cellular homeostasis.

The role of RRP15 in ribosome biogenesis links to cancer and ribosomopathies. Disruptions in normal RRP15 function may lead to abnormal cell proliferation seen in certain cancers. Its association with other ribosome assembly factors like Dyskerin can contribute to these pathological conditions. Moreover alterations in RRP15 could relate to disorders in ribosome production impacting cellular growth and leading to complex symptoms in conditions like Diamond-Blackfan anemia.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information RRP15
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 21:e1012467 PubMed40198713

2025

A targeted CRISPR screen identifies ETS1 as a regulator of HIV-1 latency.

Applications

Unspecified application

Species

Unspecified reactive species

Manickam Ashokkumar,Terry L Hafer,Abby Felton,Nancie M Archin,David M Margolis,Michael Emerman,Edward P Browne

International journal of molecular sciences 24: PubMed36834940

2023

Inhibition of Ribosomal RNA Processing 15 Homolog (RRP15) Suppressed Tumor Growth, Invasion and Epithelial to Mesenchymal Transition (EMT) of Colon Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Zirong Deng,Yun Xu,Yuchen Cai,Weiling Lin,Libei Zhang,Aoqing Jiang,Yuhang Zhou,Rui Zhao,Heyan Zhao,Zhaoguo Liu,Tingdong Yan
View all publications
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Product promise

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