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AB167579

Anti-RS1 antibody

5

(2 Reviews)

|

(2 Publications)

Mouse Polyclonal RS1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RS1.

View Alternative Names

XLRS1, RS1, Retinoschisin, X-linked juvenile retinoschisis protein

1 Images
Western blot - Anti-RS1 antibody (AB167579)
  • WB

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Western blot - Anti-RS1 antibody (AB167579)

All lanes:

Western blot - Anti-RS1 antibody (ab167579) at 1 µg/mL

Lane 1:

RS1 transfected 293T cell lysate at 15 µL

Lane 2:

Non transfected 293T cell lysate at 15 µL

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution

Predicted band size: 26 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human RS1.

O15537

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The RS1 protein also known as retinoschisin plays a critical role in cellular adhesion and retinal structure maintenance. It has a molecular mass of approximately 24 kDa. Scientists have observed RS1 expression specifically in the retina suggesting it has a specialized function in retinal health and vision. The protein exists in a dimeric form allowing it to interact efficiently with cellular membranes and extracellular matrices. Its expression is not found in frozen retina samples suggesting changes occur post-mortem or under preservation.
Biological function summary

RS1 is involved in maintaining the structural organization of the retinal layers. It participates in forming a protein complex that helps maintain the extracellular space and regulates cellular adhesion within the retina contributing to the integrity and stability of retinal architecture. The structure of the retina is important for proper signal transduction related to visual processing. The RS1 protein acts as a stabilizing factor reducing retinal detachment and disruptions that can impact vision clarity and focus.

Pathways

Retinoschisin interacts with cellular adhesion pathways and signal transduction within retinal cells. This protein appears to influence the Wnt signaling pathway which plays a role in cell-to-cell communication in the retina. Additionally RS1 associates with the neuropilin protein family which includes proteins involved in axon guidance and vascular patterning therefore influencing the development and maintenance of the retinal structure. These pathways highlight the potential impact of RS1 on visual processing and retinal health.

RS1 mutations have links to X-linked juvenile retinoschisis a retinal disorder leading to vision impairment in males. This disorder manifests as splitting of the retinal layers affecting visual acuity. RS1 interacts with laminin a protein involved in the extracellular matrix and disruptions in this interaction may contribute to disease pathogenesis. Research has also observed RS1's role in retinitis pigmentosa where progressive vision loss occurs and understanding its function provides insights into therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (By similarity). May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells (PubMed : 27114531). Required for normal structure and function of the retina (PubMed : 19093009).
See full target information RS1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 25: PubMed39125773

2024

Early Developmental Characteristics and Features of a Three-Dimensional Retinal Organoid Model of X-Linked Juvenile Retinoschisis.

Applications

Unspecified application

Species

Unspecified reactive species

Jung Woo Han,Hun Soo Chang,Sung Chul Park,Jin Young Yang,Ye Ji Kim,Jin Ha Kim,Hyo Song Park,Han Jeong,Junwon Lee,Chang Ki Yoon,Hyung Gon Yu,Se Joon Woo,Jungmook Lyu,Tae Kwann Park

The Journal of cell biology 210:1075-83 PubMed26416961

2015

Müller glia provide essential tensile strength to the developing retina.

Applications

Unspecified application

Species

Unspecified reactive species

Ryan B MacDonald,Owen Randlett,Julia Oswald,Takeshi Yoshimatsu,Kristian Franze,William A Harris
View all publications
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