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AB233428

Anti-RS1 antibody

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(1 Publication)

Rabbit Polyclonal RS1 antibody. Suitable for WB and reacts with Recombinant full length protein - Human, Pig samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RS1.

View Alternative Names

XLRS1, RS1, Retinoschisin, X-linked juvenile retinoschisis protein

2 Images
Western blot - Anti-RS1 antibody (AB233428)
  • WB

Supplier Data

Western blot - Anti-RS1 antibody (AB233428)

All lanes:

Western blot - Anti-RS1 antibody (ab233428) at 2 µg/mL

All lanes:

Pig eye tissue lysate.

Predicted band size: 26 kDa

false

Western blot - Anti-RS1 antibody (AB233428)
  • WB

Supplier Data

Western blot - Anti-RS1 antibody (AB233428)

All lanes:

Western blot - Anti-RS1 antibody (ab233428) at 2 µg/mL

All lanes:

Recombinant human RS1 protein

Predicted band size: 26 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Pig

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human RS1.

O15537

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>" }, "Recombinant full length protein - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: 55.77% Glycerol (glycerin, glycerine), 44.219% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The RS1 protein also known as retinoschisin plays a critical role in cellular adhesion and retinal structure maintenance. It has a molecular mass of approximately 24 kDa. Scientists have observed RS1 expression specifically in the retina suggesting it has a specialized function in retinal health and vision. The protein exists in a dimeric form allowing it to interact efficiently with cellular membranes and extracellular matrices. Its expression is not found in frozen retina samples suggesting changes occur post-mortem or under preservation.
Biological function summary

RS1 is involved in maintaining the structural organization of the retinal layers. It participates in forming a protein complex that helps maintain the extracellular space and regulates cellular adhesion within the retina contributing to the integrity and stability of retinal architecture. The structure of the retina is important for proper signal transduction related to visual processing. The RS1 protein acts as a stabilizing factor reducing retinal detachment and disruptions that can impact vision clarity and focus.

Pathways

Retinoschisin interacts with cellular adhesion pathways and signal transduction within retinal cells. This protein appears to influence the Wnt signaling pathway which plays a role in cell-to-cell communication in the retina. Additionally RS1 associates with the neuropilin protein family which includes proteins involved in axon guidance and vascular patterning therefore influencing the development and maintenance of the retinal structure. These pathways highlight the potential impact of RS1 on visual processing and retinal health.

RS1 mutations have links to X-linked juvenile retinoschisis a retinal disorder leading to vision impairment in males. This disorder manifests as splitting of the retinal layers affecting visual acuity. RS1 interacts with laminin a protein involved in the extracellular matrix and disruptions in this interaction may contribute to disease pathogenesis. Research has also observed RS1's role in retinitis pigmentosa where progressive vision loss occurs and understanding its function provides insights into therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (By similarity). May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells (PubMed : 27114531). Required for normal structure and function of the retina (PubMed : 19093009).
See full target information RS1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Tohoku journal of experimental medicine 264:9-19 PubMed38839357

2024

Shenqi Qiangjing Granules Ameliorate Asthenozoospermia in Mice by Regulating Ferroptosis through the METTL3/GPX4 Signaling Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Qiuyu Lu,Jiabao Ma,Luying Wei,Jing Fu,Xiaoxia Li,Kedao Lai,Xin Li,Bingyu Xia,Bin Bin,Aicun Tang
View all publications
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Product promise

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