Rabbit Polyclonal RSK3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RPS6KA2 aa 200-400.
View Alternative Names
MAPKAPK1C, RSK3, RPS6KA2, Ribosomal protein S6 kinase alpha-2, S6K-alpha-2, 90 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, Ribosomal S6 kinase 3, pp90RSK3, p90-RSK 2, p90RSK2, MAPK-activated protein kinase 1c, MAPKAP kinase 1c, MAPKAPK-1c, RSK-3
- ICC/IF
Supplier Data
Immunocytochemistry/ Immunofluorescence - Anti-RSK3 antibody (AB238332)
HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for RSK3 (Green) using ab238332 at a 1/66 dilution in ICC/IF.
The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal goat serum. The cells were then incubated with the primary antibody overnight at 4°C. Secondary used is an Alexa-Fluor®488-conjugated Goat Anti-Rabbit IgG (H+L). Counterstained with DAPI.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RSK3 antibody (AB238332)
Paraffin-embedded human lung cancer tissue stained for RSK3 with ab238332 at a 1/100 dilution in immunohistochemical analysis.
Reactivity data
Properties and storage information
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Appropriate short-term storage duration
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Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
RSK3 acts in cell growth survival and differentiation. The kinase participates in forming signaling complexes that transmit signals from the cell membrane to the nucleus. RSK3 modulates the activity of several substrates including transcription factors and other kinases by phosphorylating specific serine/threonine residues. RSK3 interacts with complexes involved in cell adhesion and migration facilitating cellular responses to external stimuli.
Pathways
RSK3 plays a role in the MAPK/ERK pathway which is important for mediating responses to growth factors. This pathway interlinks with other signaling cascades including those involving the PI3K/AKT pathway. RSK3 phosphorylates substrates such as ribosomal protein S6 and the transcription factor CREB which influence protein synthesis and gene expression. Its related proteins such as RSK1 and RSK2 also contribute to fine-tuning these cellular pathways.
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Target data
Publications (1)
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Oncology letters 29:15 PubMed39492940
2024
Applications
Unspecified application
Species
Unspecified reactive species
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