Anti-RSPH9 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

RSPH9 also known as Radial Spoke Head 9 Homolog is a protein with an approximate mass of 29 kDa. It plays a mechanical role in the structural integrity and function of cilia and flagella acting as an important element of the radial spoke complex. Expression of RSPH9 is found mainly in tissues with motile cilia such as the respiratory epithelium brain ventricles and the reproductive system. The protein stabilizes this complex facilitating proper movement of cilia and flagella.

Biological function summary

The radial spoke complex containing RSPH9 works together to regulate the bending of axonemes which is essential for ciliary and flagellar motility. RSPH9 assists with converting chemical energy into motion enabling effective fluid movement across surfaces or propulsion of cells. It forms part of a larger assembly that includes other radial spoke and axonemal dynein proteins each contributing to coordinated movement necessary for normal physiological functions.

Pathways

Effective ciliary function relies on the coordination of RSPH9 with proteins involved in the dynein-arm activation and intraflagellar transport. RSPH9 associates with the dynein regulatory complex pathway that directly affects ciliary beat frequency. Interaction with proteins such as dynein heavy chain (DNAH5) and intraflagellar transport complex facilitates the intricate process of axonemal microtubule arrangement and transportation required for normal cellular function.

Associated diseases and disorders

Defects in RSPH9 are linked to conditions like Primary Ciliary Dyskinesia (PCD) and certain types of male infertility due to impaired motility of sperm flagella. These disorders arise due to mutations that disrupt the normal structure and function of cilia and flagella. Proteins such as radial spoke head protein 4 homolog (RSPH4A) also contribute to these conditions with both RSPH9 and RSPH4A frequently identified in genetic studies of PCD highlighting their critical roles in maintaining ciliary function.