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AB106650

Anti-RSRC1 antibody

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(2 Publications)

Rabbit Polyclonal RSRC1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human RSRC1.

View Alternative Names

SRRP53, BM-011, RSRC1, Serine/Arginine-related protein 53, SRrp53, Arginine/serine-rich coiled-coil protein 1

1 Images
Western blot - Anti-RSRC1 antibody (AB106650)
  • WB

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Western blot - Anti-RSRC1 antibody (AB106650)

Lane 1:

Western blot - Anti-RSRC1 antibody (ab106650) at 1 µg/mL

Lane 2:

Western blot - Anti-RSRC1 antibody (ab106650) at 2 µg/mL

All lanes:

HepG2 cell lysate at 15 µg

Predicted band size: 38 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human RSRC1. The exact immunogen used to generate this antibody is proprietary information.

Q96IZ7

Specificity

Two isoforms of RSRC1 are known to exist; ab106650 will detect both.

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RSRC1 also known as SR-related CTD-associated factor 1 functions in the pre-mRNA splicing process. It acts as part of the spliceosome machinery necessary for accurate RNA editing. The protein possesses a molecular mass of approximately 66 kDa. RSRC1 is widely expressed in various tissues including the brain and muscle which indicates its essential role across different physiological systems.
Biological function summary

RSRC1 facilitates the regulation of alternative splicing contributing to the diversity of mRNA transcripts that are generated from a single gene. It forms part of the spliceosome complex coordinating with other splicing factors to execute precise exon-intron recognition and removal. This regulation ensures proper mRNA maturation which is essential for producing functional proteins. This protein's activity reflects its critical role in maintaining genetic instructions' integrity and reliability.

Pathways

The RSRC1 protein plays an important role in both the spliceosome and mRNA surveillance pathways. Within these pathways RSRC1 interacts with several splicing proteins including SR proteins and U2AF to modulate the assembly and function of the spliceosome. Proper functioning of these pathways ensures effective mRNA proofreading and prevents errors in mRNA processing contributing to faithful gene expression.

RSRC1 shows associations with certain neurological and muscular conditions. Research links this protein to risks of developmental disorders like autism spectrum disorder and may contribute to muscular dystrophies. Misregulation of splicing linked to RSRC1 can disrupt neuronal development and muscle function. Furthermore RSRC1's connections to SR proteins emphasize its involvement in splicing abnormalities often causing or exacerbating these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Has a role in alternative splicing and transcription regulation (PubMed : 29522154). Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing.
See full target information RSRC1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Brain : a journal of neurology 141:961-970 PubMed29522154

2018

RSRC1 mutation affects intellect and behaviour through aberrant splicing and transcription, downregulating IGFBP3.

Applications

Unspecified application

Species

Unspecified reactive species

Yonatan Perez,Shay Menascu,Idan Cohen,Rotem Kadir,Omer Basha,Zamir Shorer,Hila Romi,Gal Meiri,Tatiana Rabinski,Rivka Ofir,Esti Yeger-Lotem,Ohad S Birk

PLoS genetics 13:e1006787 PubMed28545128

2017

Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Lee D McDaniel,Karina L Conkrite,Xiao Chang,Mario Capasso,Zalman Vaksman,Derek A Oldridge,Anna Zachariou,Millicent Horn,Maura Diamond,Cuiping Hou,Achille Iolascon,Hakon Hakonarson,Nazneen Rahman,Marcella Devoto,Sharon J Diskin
View all publications
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