Rabbit Polyclonal RSRC1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human RSRC1.
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Publications
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- Brain : a journal of neurology 141:961-9702018RSRC1 mutation affects intellect and behaviour through aberrant splicing and transcription, downregulating IGFBP3.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYonatan Perez,Shay Menascu,Idan Cohen,Rotem Kadir,Omer Basha,Zamir Shorer,Hila Romi,Gal Meiri,Tatiana Rabinski,Rivka Ofir,Esti Yeger-Lotem,Ohad S BirkPubMed 29522154
- PLoS genetics 13:e10067872017Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLee D McDaniel et. al.PubMed 28545128
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human RSRC1. The exact immunogen used to generate this antibody is proprietary information. Database link Q96IZ7
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1.00000-2.00000 µg/mL | Notes - |
Target data
Function
Has a role in alternative splicing and transcription regulation (PubMed:29522154). Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing.
Alternative names
SRRP53, BM-011, RSRC1, Serine/Arginine-related protein 53, SRrp53, Arginine/serine-rich coiled-coil protein 1
Recommended products
Rabbit Polyclonal RSRC1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human RSRC1.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human RSRC1. The exact immunogen used to generate this antibody is proprietary information. Database link Q96IZ7
- Purification technique
- Affinity purification Immunogen
- Specificity
Two isoforms of RSRC1 are known to exist; ab106650 will detect both.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- Up to 12 months
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
RSRC1 also known as SR-related CTD-associated factor 1 functions in the pre-mRNA splicing process. It acts as part of the spliceosome machinery necessary for accurate RNA editing. The protein possesses a molecular mass of approximately 66 kDa. RSRC1 is widely expressed in various tissues including the brain and muscle which indicates its essential role across different physiological systems.
- Biological function summary
RSRC1 facilitates the regulation of alternative splicing contributing to the diversity of mRNA transcripts that are generated from a single gene. It forms part of the spliceosome complex coordinating with other splicing factors to execute precise exon-intron recognition and removal. This regulation ensures proper mRNA maturation which is essential for producing functional proteins. This protein's activity reflects its critical role in maintaining genetic instructions' integrity and reliability.
- Pathways
The RSRC1 protein plays an important role in both the spliceosome and mRNA surveillance pathways. Within these pathways RSRC1 interacts with several splicing proteins including SR proteins and U2AF to modulate the assembly and function of the spliceosome. Proper functioning of these pathways ensures effective mRNA proofreading and prevents errors in mRNA processing contributing to faithful gene expression.
- Associated diseases and disorders
RSRC1 shows associations with certain neurological and muscular conditions. Research links this protein to risks of developmental disorders like autism spectrum disorder and may contribute to muscular dystrophies. Misregulation of splicing linked to RSRC1 can disrupt neuronal development and muscle function. Furthermore RSRC1's connections to SR proteins emphasize its involvement in splicing abnormalities often causing or exacerbating these diseases.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-RSRC1 antibody (ab106650)
Lane 1: Western blot - Anti-RSRC1 antibody (ab106650) at 1 µg/mL
Lane 2: Western blot - Anti-RSRC1 antibody (ab106650) at 2 µg/mL
All lanes: HepG2 cell lysate at 15 µg
Predicted band size: 38 kDa
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