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AB85557

Anti-RTEL1 antibody

1

(1 Review)

|

(1 Publication)

Rabbit Polyclonal RTEL1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RTEL1.

View Alternative Names

C20orf41, KIAA1088, NHL, RTEL1, Regulator of telomere elongation helicase 1, Novel helicase-like

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RTEL1 antibody (AB85557)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RTEL1 antibody (AB85557)

Immunohistochemical analysis of formalin-fixed paraffin-embedded human small intestine tissue using ab85557 at a dilution of 5 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human RTEL1. The exact immunogen used to generate this antibody is proprietary information.

Q9NZ71

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
Preservative: 0.01% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RTEL1 also known as Regulator of Telomere Elongation Helicase 1 is a helicase protein involved in DNA metabolism. It has a molecular mass of approximately 143 kDa. RTEL1 expresses mainly in the nucleus with high expression in tissues like the testes liver and heart. Mechanistically RTEL1 functions by unwinding DNA during replication and repair processes. This activity helps maintain the integrity of telomeres and prevents telomere dysfunction.
Biological function summary

This protein plays a role in maintaining genome stability and integrity. RTEL1 functions as part of the shelterin complex which protects telomeres from being recognized as DNA damage sites. It interacts with other proteins like TRF2 and POT1 to ensure proper telomere length regulation. By dismantling DNA secondary structures RTEL1 allows for efficient DNA replication and prevents replication stress.

Pathways

Researchers have linked RTEL1 to important pathways involving DNA repair and replication. RTEL1 participates in the homologous recombination and non-homologous end joining pathways which are critical for fixing DNA double-strand breaks. Within these pathways RTEL1 interacts with proteins such as BRCA1 and RAD51 aiding in the resolution of recombination intermediates and maintenance of chromosomal stability.

RTEL1 mutations have associations with various forms of cancer and dyskeratosis congenita. In cancer RTEL1 dysfunction leads to genomic instability contributing to tumorigenesis. In dyskeratosis congenita telomere shortening due to RTEL1 defects results in premature aging and bone marrow failure. The protein associates with TERT in these conditions highlighting its role in telomere length regulation critical for cellular aging and proliferation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.
See full target information RTEL1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Physiological reports 13:e70553 PubMed40969143

2025

Midkine promotes PDGF-BB-induced proliferation, migration, and glycolysis of airway smooth muscle cells via the PI3K Akt pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yongtian Xu,Wenli Li,Jun Shi,Yanfang Guo
View all publications
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Product promise

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