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AB155304

Anti-RTN4IP1 antibody

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(3 Publications)

Rabbit Polyclonal RTN4IP1 antibody. Suitable for WB and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RTN4IP1 aa 1-250.

View Alternative Names

NIMP, RTN4IP1, NOGO-interacting mitochondrial protein, Reticulon-4-interacting protein 1

1 Images
Western blot - Anti-RTN4IP1 antibody (AB155304)
  • WB

Unknown

Western blot - Anti-RTN4IP1 antibody (AB155304)

10% SDS PAGE

All lanes:

Western blot - Anti-RTN4IP1 antibody (ab155304) at 1/1000 dilution

All lanes:

Mouse heart whole cell lysate. at 50 µg

Predicted band size: 44 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human RTN4IP1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q8WWV3

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RTN4IP1 also known as NIMP or OPA10 is a mitochondrial protein with a molecular weight of approximately 48 kDa. This protein is expressed in various tissues with higher levels observed in the brain and muscle tissues. Mechanically RTN4IP1 interacts with several mitochondrial-related proteins contributing to processes like cellular respiration and energy production. It is considered important for maintaining mitochondrial function and structure.
Biological function summary

The function of RTN4IP1 involves its role in mitochondrial dynamics and energy metabolism. It is a part of a multi-protein complex that includes members of the reticulon family which contribute to the shaping of the mitochondrial network. This complex interaction is essential for optimal oxidative phosphorylation a process that converts nutrients into ATP the cell’s main energy currency. RTN4IP1's influence extends to the regulation of reactive oxygen species ensuring cellular homeostasis.

Pathways

RTN4IP1 plays a significant role in both the mitochondrial fission and fusion process and the oxidative phosphorylation pathway. Mitochondrial fission-fusion dynamics are critical for cellular health and are tightly regulated by interactions with proteins such as mitofusin and dynamin-related protein 1 (DRP1). In the oxidative phosphorylation pathway RTN4IP1’s activity intersects with complexes that include NADH dehydrogenase and cytochrome c oxidase. These interactions help maintain efficient electron transport which is essential for ATP synthesis.

RTN4IP1 has connections to neurodegenerative disorders and mitochondrial myopathies. Diseases like hereditary spastic paraplegia can occur due to dysfunction in this protein’s mitochondrial roles leading to impaired energy metabolism. Mutations impacting RTN4IP1 are associated with optic atrophy where it interacts with optic atrophy 1 (OPA1) another protein linked to mitochondrial dysfunction. These connections highlight the protein's importance in maintaining neural and muscular function and highlight its potential as a target for therapeutic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury.
See full target information RTN4IP1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Balkan medical journal 40:205-214 PubMed37000116

2023

Ubiquitin-specific protease 11 Aggravates Ischemia-reperfusion-induced Cardiomyocyte Pyroptosis and Injury by Promoting TRAF3 Deubiquitination

Applications

Unspecified application

Species

Unspecified reactive species

Yunfei Zhang,Juledezi Hailati,Xiaoyun Ma,Hasidaer Midilibieke,Zhiqiang Liu

Cells 11: PubMed36231115

2022

A Novel Homozygous Founder Variant of in Two Consanguineous Saudi Families.

Applications

Unspecified application

Species

Unspecified reactive species

Mazhor Aldosary,Maysoon Alsagob,Hanan AlQudairy,Ana C González-Álvarez,Stefan T Arold,Mohammad Anas Dababo,Omar A Alharbi,Rawan Almass,AlBandary AlBakheet,Dalia AlSarar,Alya Qari,Mysoon M Al-Ansari,Monika Oláhová,Saif A Al-Shahrani,Moeenaldeen AlSayed,Dilek Colak,Robert W Taylor,Mohammed AlOwain,Namik Kaya

Journal of molecular neuroscience : MN 68:640-646 PubMed31077085

2019

Whole Exome Sequencing Identifies Two Novel Mutations in the Reticulon 4-Interacting Protein 1 Gene in a Chinese Family with Autosomal Recessive Optic Neuropathies.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Huan Zou,Xin-Xin Guo,Hui-Zhen Su,Chong Wang,En-Lin Dong,Ning Wang,Wan-Jin Chen,Qi-Jie Zhang
View all publications
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Product promise

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