Anti-RTN4IP1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

RTN4IP1 also known as NIMP or OPA10 is a mitochondrial protein with a molecular weight of approximately 48 kDa. This protein is expressed in various tissues with higher levels observed in the brain and muscle tissues. Mechanically RTN4IP1 interacts with several mitochondrial-related proteins contributing to processes like cellular respiration and energy production. It is considered important for maintaining mitochondrial function and structure.

Biological function summary

The function of RTN4IP1 involves its role in mitochondrial dynamics and energy metabolism. It is a part of a multi-protein complex that includes members of the reticulon family which contribute to the shaping of the mitochondrial network. This complex interaction is essential for optimal oxidative phosphorylation a process that converts nutrients into ATP the cell’s main energy currency. RTN4IP1's influence extends to the regulation of reactive oxygen species ensuring cellular homeostasis.

Pathways

RTN4IP1 plays a significant role in both the mitochondrial fission and fusion process and the oxidative phosphorylation pathway. Mitochondrial fission-fusion dynamics are critical for cellular health and are tightly regulated by interactions with proteins such as mitofusin and dynamin-related protein 1 (DRP1). In the oxidative phosphorylation pathway RTN4IP1’s activity intersects with complexes that include NADH dehydrogenase and cytochrome c oxidase. These interactions help maintain efficient electron transport which is essential for ATP synthesis.

Associated diseases and disorders

RTN4IP1 has connections to neurodegenerative disorders and mitochondrial myopathies. Diseases like hereditary spastic paraplegia can occur due to dysfunction in this protein’s mitochondrial roles leading to impaired energy metabolism. Mutations impacting RTN4IP1 are associated with optic atrophy where it interacts with optic atrophy 1 (OPA1) another protein linked to mitochondrial dysfunction. These connections highlight the protein's importance in maintaining neural and muscular function and highlight its potential as a target for therapeutic interventions.