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AB139811

Anti-RUTBC1 antibody

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(1 Publication)

Rabbit Polyclonal RUTBC1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SGSM2.

View Alternative Names

KIAA0397, RUTBC1, SGSM2, Small G protein signaling modulator 2, RUN and TBC1 domain-containing protein 1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RUTBC1 antibody (AB139811)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RUTBC1 antibody (AB139811)

Immunofluorescence of RUTBC1 in Human brain tissue with ab139811 at 20 ug/mL.

Western blot - Anti-RUTBC1 antibody (AB139811)
  • WB

Unknown

Western blot - Anti-RUTBC1 antibody (AB139811)

All lanes:

Western blot - Anti-RUTBC1 antibody (ab139811) at 1 µg/mL

Lane 1:

Human cerebellum tissue lysate at 15 µg

Lane 2:

Human cerebellum tissue lysate at 15 µg with blocking peptide

Predicted band size: 113 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human SGSM2. The exact immunogen used to generate this antibody is proprietary information.

O43147

Specificity

Multiple isoforms of RUTBC1 are known to exist. ab139811 is predicted to not cross react with other SGSM family proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RUTBC1 also known as Rab GTPase-activating protein 1 weighs approximately 140 kDa. It serves as a GTPase-activating protein (GAP) to regulate Rab proteins involved in membrane traffic. Most commonly cells express RUTBC1 in brain and muscle tissue mediating processes like vesicle formation and fusion. The gene for RUTBC1 encodes for a protein that features a variety of domains necessary for its function including a RUN domain and a TBC (Tre-2/Bub2/Cdc16) domain.
Biological function summary

Proteins interacting through RUTBC1 regulate processes involving membrane trafficking and cellular dynamics. RUTBC1 often forms part of larger multiprotein complexes that modulate the activity of Rab GTPases. Its expression ensures cells properly direct vesicle transport influencing endocytosis and exocytosis. These processes are important for maintaining cellular homeostasis and signal transduction impacting how cells respond to their external environment.

Pathways

RUTBC1 contributes importantly to the Rab GTPase signaling pathway. By deactivating Rab proteins it affects pathways essential for intracellular membrane trafficking like the endocytic and recycling pathways. RUTBC1 works alongside proteins like Rab5 and Rab7 which are key regulators of early and late endosome dynamics respectively. This collaboration ensures efficient packaging and delivery of cellular materials to proper destinations within a cell.

Research links RUTBC1 to certain neurological disorders and muscle-related diseases. Aberrant functioning of RUTBC1 could disrupt vesicle trafficking leading to conditions like Charcot-Marie-Tooth disease. Associations with neurodegenerative disorders have been noted where RUTBC1 malfunction impacts proteins like TDP-43 contributing to pathological processes. Understanding RUTBC1's interactions and effects could inform therapeutic strategies for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PubMed : 21808068, PubMed : 26620560). Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed : 26620560).
See full target information SGSM2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cellular and molecular life sciences : CMLS 82:332 PubMed40892098

2025

DDX60 protects ischemic myocardial injury and heart dysfunction by improving mitochondrial function via promoting Arl2 mRNA translation.

Applications

Unspecified application

Species

Unspecified reactive species

Tianyou Yuan,Changzuan Zhou,Yifan Long,Xiaoqiang Chen,Longzhe Gao,Ya Li,Songwen Chen,Xiaofeng Lu,Juan Xu,Xiaoyu Wu,Genqing Zhou,Shaowen Liu,Wenyi Yang,Yong Wei,Lidong Cai
View all publications
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Product promise

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