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Rabbit Polyclonal RXFP1 antibody. N-terminal. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human RXFP1.


Images

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human RXFP1. The exact immunogen used to generate this antibody is proprietary information. Database link Q9HBX9
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested
Mouse
Predicted
Rat
Predicted
Cow
Predicted
Gorilla
Predicted
Monkey
Predicted
Orangutan
Predicted

Tested
Tested

Species

Human

Dilution info

10.00000-13.00000 µg/mL

Notes

Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.

Predicted
Predicted

Species

Mouse, Rat, Cow, Monkey, Orangutan, Gorilla

Dilution info

-

Notes

-

Target data

Function

Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.

Alternative names

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Rabbit Polyclonal RXFP1 antibody. N-terminal. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human RXFP1.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Synthetic Peptide within Human RXFP1. The exact immunogen used to generate this antibody is proprietary information. Database link Q9HBX9
Purification technique

Affinity purification Immunogen

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

Biological function summary

RXFP1 plays important roles in reproductive and cardiovascular systems. It facilitates the actions of relaxin often as part of a receptor-ligand complex leading to vasodilation extracellular matrix remodeling and collagen degradation. These functions enable tissue growth and flexibility especially during pregnancy and maintain homeostasis in cardiovascular conditions by influencing heart rate and blood flow.

Activity summary

The Relaxin Family Peptide Receptor 1 commonly known as RXFP1 is a G protein-coupled receptor with a mass that can vary depending on post-translational modifications but is purified at roughly 86 kDa. RXFP1 is mainly expressed in reproductive tissues such as the uterus and cervix as well as in the heart blood vessels and kidneys. It binds with its ligand relaxin to initiate intracellular signaling cascades that activate various physiological responses.

Pathways

RXFP1 figures prominently in the nitric oxide signaling pathway and the cAMP-dependent pathway. The receptor's activation by relaxin promotes nitric oxide production which leads to vasodilation and decreased vascular resistance. It also initiates the cAMP pathway by coupling with G-proteins to increase cAMP levels which further amplifies vasodilation effects. These pathways involve proteins such as nitric oxide synthase and adenylate cyclase that interact directly or indirectly with RXFP1.

Associated diseases and disorders

RXFP1's role is particularly significant in fibrotic diseases and heart failure. Improper regulation of RXFP1-mediated collagen remodeling can contribute to tissue fibrosis with relaxin and collagen being the critical proteins in this process. Moreover the receptor's ability to mediate vasodilation and reduce cardiac load presents it as a potential therapeutic target in heart failure. By affecting these pathways RXFP1 may provide routes to novel treatments for such debilitating conditions.

Product promise

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1 product image

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RXFP1 antibody - N-terminal (ab188746), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RXFP1 antibody - N-terminal (ab188746)

    Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human uterus endometrium tissue labeling RXFP1 with ab188746 at 10 μg/ml.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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