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BiochemicalsProteins and Peptides
Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Rabbit Polyclonal RXFP1 antibody. N-terminal. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human RXFP1.
IgG
Rabbit
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
IHC-P | |
---|---|
Human | Tested |
Mouse | Predicted |
Rat | Predicted |
Cow | Predicted |
Gorilla | Predicted |
Monkey | Predicted |
Orangutan | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 10.00000-13.00000 µg/mL | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat, Cow, Monkey, Orangutan, Gorilla | Dilution info - | Notes - |
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
Relaxin receptor 1, Leucine-rich repeat-containing G-protein coupled receptor 7, Relaxin family peptide receptor 1, LGR7, RXFP1
Rabbit Polyclonal RXFP1 antibody. N-terminal. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human RXFP1.
Relaxin receptor 1, Leucine-rich repeat-containing G-protein coupled receptor 7, Relaxin family peptide receptor 1, LGR7, RXFP1
IgG
Rabbit
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
Affinity purification Immunogen
BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
RXFP1 plays important roles in reproductive and cardiovascular systems. It facilitates the actions of relaxin often as part of a receptor-ligand complex leading to vasodilation extracellular matrix remodeling and collagen degradation. These functions enable tissue growth and flexibility especially during pregnancy and maintain homeostasis in cardiovascular conditions by influencing heart rate and blood flow.
The Relaxin Family Peptide Receptor 1 commonly known as RXFP1 is a G protein-coupled receptor with a mass that can vary depending on post-translational modifications but is purified at roughly 86 kDa. RXFP1 is mainly expressed in reproductive tissues such as the uterus and cervix as well as in the heart blood vessels and kidneys. It binds with its ligand relaxin to initiate intracellular signaling cascades that activate various physiological responses.
RXFP1 figures prominently in the nitric oxide signaling pathway and the cAMP-dependent pathway. The receptor's activation by relaxin promotes nitric oxide production which leads to vasodilation and decreased vascular resistance. It also initiates the cAMP pathway by coupling with G-proteins to increase cAMP levels which further amplifies vasodilation effects. These pathways involve proteins such as nitric oxide synthase and adenylate cyclase that interact directly or indirectly with RXFP1.
RXFP1's role is particularly significant in fibrotic diseases and heart failure. Improper regulation of RXFP1-mediated collagen remodeling can contribute to tissue fibrosis with relaxin and collagen being the critical proteins in this process. Moreover the receptor's ability to mediate vasodilation and reduce cardiac load presents it as a potential therapeutic target in heart failure. By affecting these pathways RXFP1 may provide routes to novel treatments for such debilitating conditions.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human uterus endometrium tissue labeling RXFP1 with ab188746 at 10 μg/ml.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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