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AB95449

Anti-RXFP2 antibody

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(1 Publication)

Rabbit Polyclonal RXFP2 antibody. Suitable for WB, IHC-P, IHC-Fr and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RXFP2.

View Alternative Names

GPR106, GREAT, LGR8, RXFP2, Relaxin receptor 2, G-protein coupled receptor 106, G-protein coupled receptor affecting testicular descent, Leucine-rich repeat-containing G-protein coupled receptor 8, Relaxin family peptide receptor 2

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB, IHC-Fr

applications

Immunogen

Synthetic Peptide within Human RXFP2. The exact immunogen used to generate this antibody is proprietary information.

Q8WXD0

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Reactivity data

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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RXFP2 also known as Relaxin/insulin-like family peptide receptor 2 acts as a G protein-coupled receptor. This protein has a molecular mass of approximately 86 kDa and researchers have found it most abundantly expressed in the reproductive organs such as the testes and in some brain regions. RXFP2 binds to its ligand INSL3 which activates a cascade of signaling events inside the cell. When this receptor is engaged it mobilizes intracellular calcium and activates cyclic AMP pathways playing an important role in communication within the cell.
Biological function summary

The RXFP2 receptor is important for reproductive health and development. It facilitates the descent of testes in male development a process essential for normal fertility. RXFP2 operates not as a part of a large complex but rather it interacts closely with signaling molecules like INSL3. The activation of the RXFP2 receptor impacts the maturation of male reproductive organs and influences the production of sex hormones. Its function supports normal male reproductive anatomy through hormonal pathways.

Pathways

The RXFP2 receptor is essential in the reproductive and endocrine systems. It is actively involved in the Insulin-like growth factor (IGF) signaling pathway influencing cellular growth and development. RXFP2 also integrates into the hormonal signaling pathway connected to testosterone a process led by interactions with proteins like the Androgen receptor. The integration of RXFP2 into these pathways highlights its role in regulating reproductive functions and hormonal balances.

Abnormalities in RXFP2 can lead to cryptorchidism a condition where one or both testes fail to descend. Both genetic mutations in RXFP2 and deregulation of its pathway with INSL3 have been linked to this disorder. Additionally studies have associated RXFP2 with testicular dysgenesis syndrome impacting fertility and reproductive health. Its improper functioning shows significant connection with the INSL3 yet also affects downstream partners like testosterone synthesis enzymes further influencing reproductive pathologies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).
See full target information RXFP2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

American journal of physiology. Gastrointestinal and liver physiology 304:G568-73 PubMed23370674

2013

Prostaglandin E(2) mediates acid-induced heartburn in healthy volunteers.

Applications

Unspecified application

Species

Unspecified reactive species

Takashi Kondo,Tadayuki Oshima,Toshihiko Tomita,Hirokazu Fukui,Jiro Watari,Hiroki Okada,Shojiro Kikuchi,Mitsuru Sasako,Takayuki Matsumoto,Charles H Knowles,Hiroto Miwa
View all publications
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Product promise

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