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AB235274

Anti-S Opsin/BCP antibody

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(4 Publications)

Goat Polyclonal S Opsin/BCP antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 4 publications.

View Alternative Names

Bcp, Opn1sw, Short-wave-sensitive opsin 1, S opsin, Blue cone photoreceptor pigment, Blue-sensitive opsin, Short wavelength-sensitive cone opsin, BOP

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-S Opsin/BCP antibody (AB235274)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-S Opsin/BCP antibody (AB235274)

Formalin-fixed, paraffin-embedded mouse eye tissue stained for S Opsin/BCP using ab235274 at a 1/100 dilution (30mins at RT) followed by a donkey anti-goat (HRP) secondary at 4μl/ml (20mins at RT).

Panel A : Mouse retina H&E.

Panel B : ab235274, 20X magnification.

Panel C : ab235274, 40X magnification.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p>" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
Preservative: 0.01% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

S Opsin also known as BCP or Blue Cone Photopigment is a protein involved in the visual phototransduction pathway. It belongs to the family of opsin proteins and has a mass of approximately 39 kDa. This protein is mainly expressed in the cone cells of the retina especially within the blue-sensitive cones that are responsible for color vision. S Opsin plays an important role in detecting short wavelengths of light enabling the perception of the color blue.
Biological function summary

S Opsin functions as a light-sensitive receptor involved in photoreception. It is part of the visual system complex interacting with other opsins such as L and M opsins which are sensitive to different wavelengths. Upon light activation S Opsin undergoes a conformational change which initiates a cascade of biochemical events leading to the hyperpolarization of cone cells. These signals transmit visual information from the retina to the brain contributing to color differentiation and visual acuity.

Pathways

S Opsin is integral to the phototransduction pathway an important process that converts light into electrical signals. This pathway involves various proteins including transducin a G-protein that interacts with opsins to propagate the signal initiated by light activation. Further along in the pathway phosphodiesterase acts to amplify the signal within the photoreceptor cells. The effective interaction of these proteins ensures the accurate transmission of visual information under different lighting conditions.

Defects in S Opsin are linked to conditions like tritanopia which is a form of color blindness characterized by difficulty in distinguishing blue from green. The disorder is due to the absence or malfunction of S opsins in the retina. Additionally mutations in S Opsin have an association with enhanced S-cone syndrome where over-expression of S opsins can lead to night vision problems and other retinal issues. These connections highlight the importance of S Opsin in maintaining normal color vision and highlight potential areas of research for therapeutic interventions.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal (By similarity). Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors (PubMed : 21219924, PubMed : 25416279). Involved in ensuring correct abundance and localization of retinal membrane proteins (PubMed : 25416279). May increase spectral sensitivity in dim light (PubMed : 11055434).
See full target information Opn1sw

Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Journal of nanobiotechnology 23:575 PubMed40830790

2025

Engineered MEVs for photoreceptor-targeted delivery of USP25 to alleviate diabetic retinopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Yaoxiang Sun,Shenyuan Chen,Xiaoyuan Qi,Yuntong Sun,Zhengmei Jiang,Jie Chang,Yongjun Ma,Jin Huang,Benshuai You,Fengtian Sun

Translational vision science & technology 14:14 PubMed40354066

2025

A Simple and Rapid Method for Simultaneous Isolation of Mouse Retina and RPE Wholemounts.

Applications

Unspecified application

Species

Unspecified reactive species

Jialiang Yang,Haiping Wu,Qi Li,Jiaxin Guo,Jialin Yao,Shengliu Pan,Xiawei Wu,Haotian Huang,Runfang Chen,Junnian Chen,Yubin Wang,Yue Peng,Fuhua Wu,Jing Hu

Human molecular genetics 33:1916-1928 PubMed39231530

2024

A new mouse model for PRPH2 pattern dystrophy exhibits functional compensation prior and subsequent to retinal degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Breyanna L Cavanaugh,Michelle L Milstein,R Casey Boucher,Sharon X Tan,Mario W Hanna,Adam Seidel,Rikard Frederiksen,Thomas L Saunders,Alapakkam P Sampath,Kenneth P Mitton,Dao-Qi Zhang,Andrew F X Goldberg

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2401939 PubMed38704700

2024

The Long Non-Coding RNA Obesity-Related (Obr) Contributes To Lipid Metabolism Through Epigenetic Regulation.

Applications

Unspecified application

Species

Unspecified reactive species

Suneesh Kaimala,Shareena Saeed Lootah,Neha Mehra,Challagandla Anil Kumar,Saeeda Al Marzooqi,Prabha Sampath,Suraiya Anjum Ansari,Bright Starling Emerald
View all publications

Product promise

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