JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB133312

Anti-SAA4 antibody [EPR2927]

Be the first to review this product! Submit a review

|

(0 Publication)

Rabbit Recombinant Monoclonal SAA4 antibody. Suitable for WB and reacts with Human samples.

View Alternative Names

CSAA, SAA4, Serum amyloid A-4 protein, Constitutively expressed serum amyloid A protein, C-SAA

1 Images
Western blot - Anti-SAA4 antibody [EPR2927] (AB133312)
  • WB

Unknown

Western blot - Anti-SAA4 antibody [EPR2927] (AB133312)

All lanes:

Western blot - Anti-SAA4 antibody [EPR2927] (ab133312) at 1/10000 dilution

All lanes:

Human plasma at 10 µg

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 15 kDa

false

  • Carrier free

    Anti-SAA4 antibody [EPR2927] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR2927

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

style
left-column

Alternative Products

Primary Antibodies

AB92540

Anti-SAA4 antibody [EPR2926]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-SAA4 antibody [EPR2926] (AB92540)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB199030

Anti-SAA1 + SAA2 antibody [EPR19235]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SAA1 + SAA2 antibody [EPR19235] (AB199030)

  • 0
  • 0
Proteins & Peptides

AB173023

Recombinant Human SAA4 protein

  • 0
  • 0
Primary Antibodies

AB115777

Anti-beta Actin antibody [SP124] - Cytoskeleton Marker

20ul selling size|RabMAb|Lab Essentials|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta Actin antibody [SP124] - Cytoskeleton Marker (AB115777)

  • 4
  • 1
Primary Antibodies

AB92700

Anti-IKB alpha (phospho S32) antibody [EPR3148]

20ul selling size|RabMAb|Recombinant

Immunoprecipitation - Anti-IKB alpha (phospho S32) antibody [EPR3148] (AB92700)

  • 5
  • 1
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
style
left-column

Product details

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

style
left-column

Properties and storage information

Form
Liquid
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Conditional Ambient
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Serum Amyloid A4 (SAA4) also known as C-SAA is a minor apolipoprotein associated with high-density lipoprotein (HDL) in plasma. SAA4 is a protein of approximately 14 kDa in mass. It is mainly expressed in the liver and secreted into the bloodstream. The protein exists in a tetrameric form and is part of the SAA family which has four known human isoforms: SAA1 SAA2 SAA3 and SAA4.
Biological function summary

SAA4 plays a role in lipid metabolism and transport. Unlike SAA1 and SAA2 SAA4 is not significantly upregulated during acute-phase inflammatory responses. SAA4 works by stabilizing HDL particles and influencing cholesterol transport. It does not participate actively in the inflammatory response which distinguishes it from other SAA proteins. As part of the lipoprotein complex it contributes to maintaining lipid homeostasis.

Pathways

SAA4 participates in pathways associated with lipid transport and metabolism. It is involved in the reverse cholesterol transport pathway an essential system to transfer cholesterol from tissues back to the liver. SAA4 shares functional characteristics with apolipoprotein A1 (ApoA1) another key protein in HDL metabolism. Both proteins contribute to cholesterol efflux and transport although SAA4 has more structural than regulatory roles.

SAA4 has connections to cardiovascular disease and amyloidosis. Researchers have identified altered levels of SAA4 in patients with cardiovascular conditions suggesting a link to atherosclerosis. In amyloidosis although SAA4 is not a primary amyloid component its amyloidogenic potential raises interest in studying its involvement. A clear association exists between SAA4 and ApoA1 in these disorders given their shared role in HDL structure and metabolism.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Major acute phase reactant.
See full target information SAA4
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com