AB181190

Anti-Sacsin antibody [EPR11864]

RabMAb
Recombinant
What is this?

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(5 Publications)

Rabbit Recombinant Monoclonal Sacsin antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications.

View Alternative Names

DNAJC29, KIAA0730, SACS, Sacsin, DnaJ homolog subfamily C member 29

2 Images

Supplier Data

Western blot - Anti-Sacsin antibody [EPR11864] (AB181190)

All lanes:

Western blot - Anti-Sacsin antibody [EPR11864] (ab181190) at 1/5000 dilution

All lanes:

Human glioma tissue lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 521 kDa

Observed band size: 437 kDa

false

Unknown

Western blot - Anti-Sacsin antibody [EPR11864] (AB181190)

All lanes:

Western blot - Anti-Sacsin antibody [EPR11864] (ab181190) at 1/2000 dilution

All lanes:

Human fetal brain at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 521 kDa

Observed band size: 437 kDa

false

Carrier free

Anti-Sacsin antibody [EPR11864] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR11864

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins.

See full target information SACS

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

JCI insight 8: PubMed37159335

2023

Restoring calcium homeostasis in Purkinje cells arrests neurodegeneration and neuroinflammation in the ARSACS mouse model.

Applications

Unspecified application

Species

Unspecified reactive species

Andrea Del Bondio,Fabiana Longo,Daniele De Ritis,Erica Spirito,Paola Podini,Bernard Brais,Angela Bachi,Angelo Quattrini,Francesca Maltecca

Cell reports 41:111580 PubMed36323248

2022

Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization.

Applications

Unspecified application

Species

Unspecified reactive species

Lisa E L Romano,Wen Yih Aw,Kathryn M Hixson,Tatiana V Novoselova,Tammy M Havener,Stefanie Howell,Bonnie Taylor-Blake,Charlotte L Hall,Lei Xing,Josh Beri,Suran Nethisinghe,Laura Perna,Abubakar Hatimy,Ginevra Chioccioli Altadonna,Lee M Graves,Laura E Herring,Anthony J Hickey,Konstantinos Thalassinos,J Paul Chapple,Justin M Wolter

International journal of molecular sciences 22: PubMed34769152

2021

Hsp90 Inhibition: A Promising Therapeutic Approach for ARSACS.

Applications

Unspecified application

Species

Unspecified reactive species

Suran Nethisinghe,Rosella Abeti,Maheswaran Kesavan,W Christian Wigley,Paola Giunti

Neurology 97:e2315-e2327 PubMed34649874

2021

Assessment of Sacsin Turnover in Patients With ARSACS: Implications for Molecular Diagnosis and Pathogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Fabiana Longo,Daniele De Ritis,Annarita Miluzio,Davide Fraticelli,Jonathan Baets,Marina Scarlato,Filippo M Santorelli,Stefano Biffo,Francesca Maltecca

Molecular brain 12:19 PubMed30866998

2019

Sacs R272C missense homozygous mice develop an ataxia phenotype.

Applications

Unspecified application

Species

Unspecified reactive species

Roxanne Larivière,Nicolas Sgarioto,Brenda Toscano Márquez,Rébecca Gaudet,Karine Choquet,R Anne McKinney,Alanna J Watt,Bernard Brais

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Sacsin antibody [EPR11864]

Western blot - Anti-Sacsin antibody [EPR11864] (AB181190)

Western blot - Anti-Sacsin antibody [EPR11864] (AB181190)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (5)

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Product promise