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AB67344

Anti-SAF-B2 antibody [6F7]

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(1 Publication)

Mouse Monoclonal SAF-B2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SAFB2 aa 300-400.

View Alternative Names

KIAA0138, SAFB2, Scaffold attachment factor B2, SAF-B2

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SAF-B2 antibody [6F7] (AB67344)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SAF-B2 antibody [6F7] (AB67344)

ab67344 at 5μg/ml dilution staining SAF-B2 in human brain cortex by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

6F7

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human SAFB2 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.

Q14151

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HA tag antibody [EPR22819-101] (AB236632)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SAF-B2 also known as Scaffold Attachment Factor B2 is a critical protein in cellular regulation with a molecular weight of approximately 100 kDa. It is widely expressed in the nucleus of various cell types serving a role in transcriptional regulation. As a component of the scaffold/matrix attachment regions (S/MARs) it interacts with chromosomal DNA to influence gene expression. This interaction helps in organizing chromosomal structures profoundly impacting gene accessibility and transcription processes.
Biological function summary

SAF-B2 takes part in regulating transcription and RNA processing contributing to its functional versatility. It interacts with several RNA-binding proteins as part of a nuclear protein complex. These interactions suggest SAF-B2’s involvement in RNA splicing and stabilization linking it to mRNA processing pathways. The protein plays an important role in maintaining transcriptional fidelity and ensuring appropriate cellular response to varying signals.

Pathways

SAF-B2 affects transcription and mRNA processing pathways significantly. It associates with proteins like SAF-B which also participate in chromatin remodeling and gene regulation. Both proteins contribute to the regulation of gene expression through their participation in the complex network of transcriptional pathways. Additionally SAF-B2's involvement in signaling pathways indicates its broader role in cellular communication and response modulation.

Alterations in SAF-B2 have connections to cancer and neurodegenerative diseases. Aberrant expression or mutation can disrupt normal gene regulation processes contributing to tumorigenesis or neural dysfunction. The protein's interaction with SAF-B highlights the potential for misregulated pathways to promote disease states. Understanding SAF-B2’s role in these processes aids in developing targeted therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.
See full target information SAFB2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 8:1392 PubMed29123096

2017

ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1.

Applications

Unspecified application

Species

Unspecified reactive species

Tatiana Moiseeva,Brian Hood,Sandy Schamus,Mark J O'Connor,Thomas P Conrads,Christopher J Bakkenist
View all publications
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Product promise

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