Anti-SAFB antibody

Supplementary info

Activity summary

SAFB also known as Scaffold Attachment Factor B is a protein that participates in multiple cellular functions. It has a molecular weight of approximately 135 kDa. Researchers observe its expression in the nucleus of a variety of cell types including epithelial and fibroblast cells. In a mechanical context SAFB plays a role in binding to scaffold/matrix-attachment regions (S/MARs) of DNA influencing transcription and chromatin organization.

Biological function summary

SAFB works as a multifunctional protein that regulates gene expression and RNA processing. It acts as part of protein complexes such as those involved in modulating estrogen receptor activity. SAFB interacts with chromatin and RNA acting as a bridge between these important cellular components. It influences transcription by functioning as both a transcriptional repressor and activator depending on the context within the cell.

Pathways

Several cellular interactions highlight the role of SAFB within nuclear signaling networks like the estrogen signaling pathway and stress response pathways. SAFB associates with proteins such as estrogen receptor α (ERα) and heat shock proteins (HSP) in these pathways. Its interactions help modulate dynamics within these networks impacting cellular responses to hormonal and stress stimuli.

Associated diseases and disorders

Researchers have connected SAFB with breast cancer and hormone-related conditions. In breast cancer SAFB's interaction with ERα suggests a role in cancer cell proliferation and response to hormonal therapy. Connections also exist with stress-response proteins like HSP70 indicating potential involvement in the cellular stress framework. Such relationships point towards SAFB's roles in disease progression and possible therapeutic targeting.