AB41974

Anti-SALL1 antibody [K9814]

Name: Anti-SALL1 antibody [K9814] (ab41974) | Abcam
Brand: Abcam Limited
SKU: AB41974
Price: 350 USD
Availability: InStock
Rating: 5 (2 reviews)

(2 Reviews)

(8 Publications)

Mouse Monoclonal SALL1 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SALL1 aa 250-500.

View Alternative Names

SAL1, ZNF794, SALL1, Sal-like protein 1, Spalt-like transcription factor 1, Zinc finger protein 794, Zinc finger protein SALL1, Zinc finger protein Spalt-1, HSal1, Sal-1

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL1 antibody [K9814] (AB41974)

IHC-P

AbReview50606****

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL1 antibody [K9814] (AB41974)

ab41974 staining SALL1 in Mouse embryonic kidney at tissue sections by Immunohistochemistry (IHC- P- paraformaldehyde-fixed, paraffin- embedded sections). Tissue was fixed with paraformaldehyde and blocked with 10μg/ml BSA for 1 hour at 25^oC; antigen retrieval was by heat mediation in a Tris/EDTA (pH9). Samples were incubated with primary antibody (1/100 with 6% Horse serum in PBST) for 16hours at 4^oC. An Alexa Fluor^® 568 donkey anti-mouse polyclonal (1/500 dilution) was used as the secondary antibody.

This image was generated using the ascites version of the product.

Image courtesy of an anonymous Abreview

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL1 antibody [K9814] (AB41974)

ab41974 staining SALL1 in Mouse embryo kidnet tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections).

This image was generated using the ascites version of the product.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

K9814

Isotype

IgG2a

Carrier free

Reacts with

Mouse

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SALL1 aa 250-500. The exact immunogen used to generate this antibody is proprietary information.

Q9NSC2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }

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Product details

This product was changed from ascites to tissue culture supernatant on 3^rd April 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7 Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SALL1 also known as Sal-like protein 1 is a zinc-finger transcription factor involved in the regulation of gene expression. It has a mass of about 132 kDa and is expressed in many tissues during embryonic development including the kidney brain and limb buds. SALL1 contains multiple zinc finger domains which help it bind to DNA and control the transcription of target genes.

Biological function summary

SALL1 plays an important role in the maintenance of stem cell pluripotency and tissue differentiation. It is not known for being part of any complex but interacts with other transcription factors to regulate the expression of genes necessary for normal development. Disruption in the function of SALL1 can lead to developmental defects due to improper gene regulation.

Pathways

SALL1 is involved in the Wnt signaling pathway important for developmental processes and cell fate determination. In this pathway it interacts with proteins such as β-catenin to influence cell behavior. SALL1 is also associated with the Hedgehog signaling pathway which helps in patterning and growth during embryogenesis. Through these interactions SALL1 helps coordinate complex genetic programs necessary for organismal development.

Alterations in SALL1 function are linked to Townes-Brocks syndrome a genetic condition characterized by limb ear and renal anomalies. Mutations in the SALL1 gene disrupt its ability to regulate developmental genes and lead to the phenotypic manifestations of the syndrome. Additionally SALL1 disruptions can associate with renal cancer possibly through interactions with other transcription factors like p53 which play a role in tumor suppression.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Transcriptional repressor involved in organogenesis. Plays an essential role in ureteric bud invasion during kidney development.

See full target information SALL1

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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Development (Cambridge, England) 150: PubMed37519269

2023

Induction of kidney-related gene programs through co-option of SALL1 in mole ovotestes.

Applications

Unspecified application

Species

Unspecified reactive species

Magdalena Schindler,Marco Osterwalder,Izabela Harabula,Lars Wittler,Athanasia C Tzika,Dina K N Dechmann,Martin Vingron,Axel Visel,Stefan A Haas,Francisca M Real

Nature immunology 24:1188-1199 PubMed37322178

2023

SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity.

Applications

Unspecified application

Species

Unspecified reactive species

Bethany R Fixsen,Claudia Z Han,Yi Zhou,Nathanael J Spann,Payam Saisan,Zeyang Shen,Christopher Balak,Mashito Sakai,Isidoro Cobo,Inge R Holtman,Anna S Warden,Gabriela Ramirez,Jana G Collier,Martina P Pasillas,Miao Yu,Rong Hu,Bin Li,Sarah Belhocine,David Gosselin,Nicole G Coufal,Bing Ren,Christopher K Glass

EMBO reports 24:e55843 PubMed36573342

2022

A congenital hydrocephalus-causing mutation in Trim71 induces stem cell defects via inhibiting Lsd1 mRNA translation.

Applications

Unspecified application

Species

Unspecified reactive species

Qiuying Liu,Mariah K Novak,Rachel M Pepin,Katharine R Maschhoff,Kailey Worner,Xiaoli Chen,Shaojie Zhang,Wenqian Hu

Frontiers in immunology 13:960906 PubMed36353631

2022

The significance of glycolysis index and its correlations with immune infiltrates in Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiqiang Qiu,Xuanyang Bai,Xiangwen Ji,Xiang Wang,Xinye Han,Duo Wang,Fenjun Jiang,Yihua An

Nature communications 12:6496 PubMed34764250

2021

A tissue-bioengineering strategy for modeling rare human kidney diseases in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

J O R Hernandez,X Wang,M Vazquez-Segoviano,M Lopez-Marfil,M F Sobral-Reyes,A Moran-Horowich,M Sundberg,D O Lopez-Cantu,C K Probst,G U Ruiz-Esparza,K Giannikou,R Abdi,E P Henske,D J Kwiatkowski,M Sahin,D R Lemos

Pathology oncology research : POR 27:587130 PubMed34257535

2021

Hsa_circ_0043265 Restrains Cell Proliferation, Migration and Invasion of Tongue Squamous Cell Carcinoma via Targeting the miR-1243/SALL1 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Cuijuan Qian,Yisheng Yang,Tianchen Lan,Yichao Wang,Jun Yao

Molecular cell 81:845-858.e8 PubMed33406384

2021

SALL4 controls cell fate in response to DNA base composition.

Applications

Unspecified application

Species

Unspecified reactive species

Raphaël Pantier,Kashyap Chhatbar,Timo Quante,Konstantina Skourti-Stathaki,Justyna Cholewa-Waclaw,Grace Alston,Beatrice Alexander-Howden,Heng Yang Lee,Atlanta G Cook,Cornelia G Spruijt,Michiel Vermeulen,Jim Selfridge,Adrian Bird

Oncotarget 9:7442-7452 PubMed29484122

2018

expression in acute myeloid leukemia.

Applications

Unspecified application

Species

Unspecified reactive species

Huda Salman,Xiao Shuai,Anh Thu Nguyen-Lefebvre,Banabihari Giri,Mingqiang Ren,Michael Rauchman,Lynn Robbins,Wei Hou,Hasan Korkaya,Yupo Ma

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SALL1 antibody [K9814]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL1 antibody [K9814] (AB41974)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL1 antibody [K9814] (AB41974)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (8)

Product promise