Mouse Monoclonal SALL1 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 7 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SALL1 aa 250-500.
Images
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL1 antibody [K9814] (AB41974), expandable thumbnail](https://content.abcam.com/products/images/sall1-antibody-k9814-ab41974--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img132742.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL1 antibody [K9814] (AB41974)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL1 antibody [K9814] (AB41974), expandable thumbnail](https://content.abcam.com/products/images/sall1-antibody-k9814-ab41974--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img106031.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL1 antibody [K9814] (AB41974)")
Publications
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- Nature immunology 24:1188-11992023SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBethany R Fixsen,Claudia Z Han,Yi Zhou,Nathanael J Spann,Payam Saisan,Zeyang Shen,Christopher Balak,Mashito Sakai,Isidoro Cobo,Inge R Holtman,Anna S Warden,Gabriela Ramirez,Jana G Collier,Martina P Pasillas,Miao Yu,Rong Hu,Bin Li,Sarah Belhocine,David Gosselin,Nicole G Coufal,Bing Ren,Christopher K GlassPubMed 37322178
- EMBO reports 24:e558432022A congenital hydrocephalus-causing mutation in Trim71 induces stem cell defects via inhibiting Lsd1 mRNA translation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQiuying Liu,Mariah K Novak,Rachel M Pepin,Katharine R Maschhoff,Kailey Worner,Xiaoli Chen,Shaojie Zhang,Wenqian HuPubMed 36573342
- Frontiers in immunology 13:9609062022The significance of glycolysis index and its correlations with immune infiltrates in Alzheimer's disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhiqiang Qiu,Xuanyang Bai,Xiangwen Ji,Xiang Wang,Xinye Han,Duo Wang,Fenjun Jiang,Yihua AnPubMed 36353631
- Nature communications 12:64962021A tissue-bioengineering strategy for modeling rare human kidney diseases in vivo.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJ O R Hernandez,X Wang,M Vazquez-Segoviano,M Lopez-Marfil,M F Sobral-Reyes,A Moran-Horowich,M Sundberg,D O Lopez-Cantu,C K Probst,G U Ruiz-Esparza,K Giannikou,R Abdi,E P Henske,D J Kwiatkowski,M Sahin,D R LemosPubMed 34764250
- Pathology oncology research : POR 27:5871302021Hsa_circ_0043265 Restrains Cell Proliferation, Migration and Invasion of Tongue Squamous Cell Carcinoma via Targeting the miR-1243/SALL1 Axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCuijuan Qian,Yisheng Yang,Tianchen Lan,Yichao Wang,Jun YaoPubMed 34257535
- Molecular cell 81:845-858.e82021SALL4 controls cell fate in response to DNA base composition.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRaphaël Pantier,Kashyap Chhatbar,Timo Quante,Konstantina Skourti-Stathaki,Justyna Cholewa-Waclaw,Grace Alston,Beatrice Alexander-Howden,Heng Yang Lee,Atlanta G Cook,Cornelia G Spruijt,Michiel Vermeulen,Jim Selfridge,Adrian BirdPubMed 33406384
- Oncotarget 9:7442-74522018expression in acute myeloid leukemia.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHuda Salman,Xiao Shuai,Anh Thu Nguyen-Lefebvre,Banabihari Giri,Mingqiang Ren,Michael Rauchman,Lynn Robbins,Wei Hou,Hasan Korkaya,Yupo MaPubMed 29484122
Key facts
- Isotype
- IgG2a
- Host species
- Mouse
- Storage buffer
pH: 7
Preservative: 0.1% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- Recombinant Fragment Protein within Human SALL1 aa 250-500. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NSC2
Reactivity data
Select an application| IHC-P | |
|---|---|
| Mouse | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Transcriptional repressor involved in organogenesis. Plays an essential role in ureteric bud invasion during kidney development.
Alternative names
SAL1, ZNF794, SALL1, Sal-like protein 1, Spalt-like transcription factor 1, Zinc finger protein 794, Zinc finger protein SALL1, Zinc finger protein Spalt-1, HSal1, Sal-1
Recommended products
Mouse Monoclonal SALL1 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 7 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SALL1 aa 250-500.
Key facts
- Isotype
- IgG2a
- Host species
- Mouse
- Storage buffer
pH: 7
Preservative: 0.1% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- Recombinant Fragment Protein within Human SALL1 aa 250-500. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NSC2
- Clone number
- K9814
- Purity
- Tissue culture supernatant
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was changed from ascites to tissue culture supernatant on 3rd April 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SALL1 also known as Sal-like protein 1 is a zinc-finger transcription factor involved in the regulation of gene expression. It has a mass of about 132 kDa and is expressed in many tissues during embryonic development including the kidney brain and limb buds. SALL1 contains multiple zinc finger domains which help it bind to DNA and control the transcription of target genes.
- Biological function summary
SALL1 plays an important role in the maintenance of stem cell pluripotency and tissue differentiation. It is not known for being part of any complex but interacts with other transcription factors to regulate the expression of genes necessary for normal development. Disruption in the function of SALL1 can lead to developmental defects due to improper gene regulation.
- Pathways
SALL1 is involved in the Wnt signaling pathway important for developmental processes and cell fate determination. In this pathway it interacts with proteins such as β-catenin to influence cell behavior. SALL1 is also associated with the Hedgehog signaling pathway which helps in patterning and growth during embryogenesis. Through these interactions SALL1 helps coordinate complex genetic programs necessary for organismal development.
- Associated diseases and disorders
Alterations in SALL1 function are linked to Townes-Brocks syndrome a genetic condition characterized by limb ear and renal anomalies. Mutations in the SALL1 gene disrupt its ability to regulate developmental genes and lead to the phenotypic manifestations of the syndrome. Additionally SALL1 disruptions can associate with renal cancer possibly through interactions with other transcription factors like p53 which play a role in tumor suppression.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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2 product images
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL1 antibody [K9814] (ab41974), expandable thumbnail](https://content.abcam.com/products/images/sall1-antibody-k9814-ab41974--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img132742.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL1 antibody [K9814] (ab41974)")
Image courtesy of an anonymous customer reviewImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL1 antibody [K9814] (ab41974)
ab41974 staining SALL1 in Mouse embryonic kidney at tissue sections by Immunohistochemistry (IHC- P- paraformaldehyde-fixed, paraffin- embedded sections). Tissue was fixed with paraformaldehyde and blocked with 10μg/ml BSA for 1 hour at 25oC; antigen retrieval was by heat mediation in a Tris/EDTA (pH9). Samples were incubated with primary antibody (1/100 with 6% Horse serum in PBST) for 16hours at 4oC. An Alexa Fluor® 568 donkey anti-mouse polyclonal (1/500 dilution) was used as the secondary antibody.
This image was generated using the ascites version of the product.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL1 antibody [K9814] (ab41974), expandable thumbnail](https://content.abcam.com/products/images/sall1-antibody-k9814-ab41974--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img106031.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL1 antibody [K9814] (ab41974)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL1 antibody [K9814] (ab41974)
ab41974 staining SALL1 in Mouse embryo kidnet tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections).
This image was generated using the ascites version of the product.
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