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AB69238

Anti-Salmonella typhi antibody [AC04]

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(3 Publications)

Mouse Monoclonal Salmonella typhi antibody. Suitable for ELISA, ICC/IF and reacts with Salmonella typhi samples. Cited in 3 publications. Immunogen corresponding to Cell preparation containing Salmonella typhi protein.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

AC04

Isotype

IgG1

Carrier free

No

Reacts with

Salmonella typhi

Applications

ELISA, ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

ab69238 is only reactive with Salmonella typhi.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Salmonella typhi": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.065% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Salmonella typhi also known as S. typhi is a Gram-negative flagellated bacterium with a rod-shaped structure. This pathogen is primarily responsible for causing typhoid fever in humans. It possesses a lipopolysaccharide layer which plays an important role in its virulence and its size typically falls around 0.7 to 1.5 micrometers in diameter and 2 to 5 micrometers in length. It colonizes the guts particularly the small intestine where it invades epithelial cells and can spread to the bloodstream and other tissues.
Biological function summary

S. typhi interacts with host immune cells and survives inside macrophages avoiding the host's immune response. This survival mechanism enables the pathogen to form an intracellular niche. It is often associated with various virulence factors including Vi polysaccharide capsule and type III secretion system. These factors contribute to its ability to evade host defenses and establish an infection. S. typhi does not form part of known protein complexes but the genes responsible for its virulence are critical in its pathogenicity.

Pathways

S. typhi engages in several key host-pathogen interaction pathways. Within these it utilizes the type III secretion system to inject effector proteins into the host cells manipulating host cell processes. Additionally it involves in pathways linked to immune evasion affecting signaling proteins such as cytokines and other immune mediators. Important related proteins include TLR4 and TNF-alpha which play roles in the host immune response against bacterial infection.

S. typhi is directly responsible for typhoid fever a systemic illness characterized by prolonged fever and abdominal symptoms. It is uniquely adapted to survive and proliferate in the human host. Chronic carriers of the bacterium can harbor it in the gallbladder potentially leading to gallbladder cancer in rare cases. The pathogen interacts with proteins like IFN-gamma and IL-1beta which are involved in the regulation of immune responses during infection. These interactions complicate treatment and require targeted therapies such as the use of anti-Salmonella and antityphoid vaccines and medications to reduce disease burden.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Salmonella typhi
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:4507 PubMed39915561

2025

Purpurin suppresses Salmonella invasion of host cells by reducing the secretion of T3SS-1 effector proteins.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenxu Shi,Zhimin Guo,Siqi Li,Chenxiao Jiang,Jianfeng Wang,Xuming Deng,Hongtao Liu,Jiazhang Qiu

Journal of materials chemistry. B 3:3573-3582 PubMed26417447

2015

Gold Nanoparticle Labeling Based ICP-MS Detection/Measurement of Bacteria, and Their Quantitative Photothermal Destruction.

Applications

Unspecified application

Species

Unspecified reactive species

Yunfeng Lin,Ashton T Hamme

Cellular & molecular immunology 8:83-7 PubMed21200387

2011

Humanized mice are susceptible to Salmonella typhi infection.

Applications

IHC-P

Species

Unspecified reactive species

M Firoz Mian,Elisabeth A Pek,Meghan J Chenoweth,Ali A Ashkar
View all publications
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Product promise

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