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AB234679

Anti-SAMD8 antibody

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(1 Publication)

Rabbit Polyclonal SAMD8 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SAMD8 aa 1-200.

View Alternative Names

Sphingomyelin synthase-related protein 1, SMSr, Ceramide phosphoethanolamine synthase, Phosphatidylethanolamine Phospholipase C, Sterile alpha motif domain-containing protein 8, CPE synthase, PE-PLC, SAM domain-containing protein 8, SAMD8

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SAMD8 antibody (AB234679)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SAMD8 antibody (AB234679)

Paraffin-embedded human lymph node tissue stained for SAMD8 using ab234679 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SAMD8 antibody (AB234679)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SAMD8 antibody (AB234679)

Paraffin-embedded human brain tissue stained for SAMD8 using ab234679 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SAMD8 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q96LT4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SAMD8 also known as Sterile Alpha Motif Domain Containing 8 is a protein encoded by the SAMD8 gene. This protein has a mass of approximately 56 kDa. SAMD8 plays a role in the regulation of sphingolipid metabolism and membranes organization within the cell. It is especially expressed in the brain and highly present in neuronal tissues where it contributes importantly to cellular membrane dynamics.
Biological function summary

SAMD8 influences sphingolipid metabolic processes and membrane architecture regulation. The protein has a role in synthesizing and maintaining specific lipid environments in membranes impacting cellular signaling and the movement of membrane constituents. SAMD8 is not known to be part of a well-defined multiprotein complex yet its interactions indicate collaboration with other lipid-modifying enzymes and proteins within cellular contexts.

Pathways

SAMD8 integrates into the sphingolipid metabolic pathway influencing the production and distribution of sphingomyelin and ceramides. These lipids regulate several cellular processes such as signaling and apoptosis. SAMD8 interacts with proteins like SMS (sphingomyelin synthase) which performs similar roles in lipid biosynthesis. By participating in these pathways SAMD8 contributes to broader cellular regulatory networks influencing cellular behavior and stress responses.

SAMD8 has connections to neurodegenerative conditions such as Alzheimer's disease due to its role in brain lipid homeostasis. Imbalanced lipid composition in neuronal cells can lead to disrupted neural function and degeneration. Disruptions in SAMD8 expression or function may also link to metabolic disorders including lipid storage diseases. Proteins like APP (Amyloid Precursor Protein) interact within these contexts where disruptions in lipid metabolism can exacerbate disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Has phospholipase C (PLC) activity (PubMed : 33621517, PubMed : 34332077, PubMed : 38388831). Shows specificity for phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), hydrolyzing PE to produce phosphoethanolamine and diacylglycerol (1,2-diacyl-sn-glycerol, DAG) (PubMed : 34332077). This reaction might act as a regulatory switch to activate serine palmitoyltransferase (SPT) and promote sphingolipid metabolism (By similarity). Can also function as a ceramide phosphoethanolamine (N-acylsphingoid 1-phosphoethanolamine, CPE) synthase when intracellular ceramide levels are elevated (PubMed : 19506037, PubMed : 38388831). Binds the headgroup from PE, which is smaller and more hydrophilic than the phosphocholine headgroup transferred in the canonical sphingomyelin synthesis (SMS) reaction by SMS1 or SMS2, and transfers it on to the primary hydroxyl of a ceramide in the lumen of the endoplasmic reticulum (PubMed : 19506037, PubMed : 38388831). Plays a role as a ceramide sensor, helping to regulate ceramide homeostasis in the endoplasmic reticulum, which is critical for maintaining the integrity of the early secretory pathway (PubMed : 19506037).
See full target information SAMD8
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Virus research 355:199570 PubMed40188851

2025

Common host factors for internal ribosomal entry site-mediated translation of viral genomic RNA: An investigation in foot-and-mouth disease and classical swine fever viruses.

Applications

Unspecified application

Species

Unspecified reactive species

Rupaly Akhter,Kazi Anowar Hossain,Bouchra Kitab,Yoshihiro Sakoda,Kyoko Tsukiyama-Kohara
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Product promise

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