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AB234679

Anti-SAMD8 antibody

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Rabbit Polyclonal SAMD8 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SAMD8 aa 1-200.

View Alternative Names

Sphingomyelin synthase-related protein 1, SMSr, Ceramide phosphoethanolamine synthase, Sterile alpha motif domain-containing protein 8, CPE synthase, SAM domain-containing protein 8, SAMD8

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SAMD8 antibody (AB234679)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SAMD8 antibody (AB234679)

Paraffin-embedded human brain tissue stained for SAMD8 using ab234679 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SAMD8 antibody (AB234679)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SAMD8 antibody (AB234679)

Paraffin-embedded human lymph node tissue stained for SAMD8 using ab234679 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SAMD8 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q96LT4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SAMD8 also known as Sterile Alpha Motif Domain Containing 8 is a protein encoded by the SAMD8 gene. This protein has a mass of approximately 56 kDa. SAMD8 plays a role in the regulation of sphingolipid metabolism and membranes organization within the cell. It is especially expressed in the brain and highly present in neuronal tissues where it contributes importantly to cellular membrane dynamics.
Biological function summary

SAMD8 influences sphingolipid metabolic processes and membrane architecture regulation. The protein has a role in synthesizing and maintaining specific lipid environments in membranes impacting cellular signaling and the movement of membrane constituents. SAMD8 is not known to be part of a well-defined multiprotein complex yet its interactions indicate collaboration with other lipid-modifying enzymes and proteins within cellular contexts.

Pathways

SAMD8 integrates into the sphingolipid metabolic pathway influencing the production and distribution of sphingomyelin and ceramides. These lipids regulate several cellular processes such as signaling and apoptosis. SAMD8 interacts with proteins like SMS (sphingomyelin synthase) which performs similar roles in lipid biosynthesis. By participating in these pathways SAMD8 contributes to broader cellular regulatory networks influencing cellular behavior and stress responses.

SAMD8 has connections to neurodegenerative conditions such as Alzheimer's disease due to its role in brain lipid homeostasis. Imbalanced lipid composition in neuronal cells can lead to disrupted neural function and degeneration. Disruptions in SAMD8 expression or function may also link to metabolic disorders including lipid storage diseases. Proteins like APP (Amyloid Precursor Protein) interact within these contexts where disruptions in lipid metabolism can exacerbate disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.
See full target information SAMD8
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