JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB173294

Anti-Sarcalumenin antibody [EPR12590]

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Recombinant Monoclonal Sarcalumenin antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

Sarcalumenin, SRL

1 Images
Western blot - Anti-Sarcalumenin antibody [EPR12590] (AB173294)
  • WB

Supplier Data

Western blot - Anti-Sarcalumenin antibody [EPR12590] (AB173294)

All lanes:

Western blot - Anti-Sarcalumenin antibody [EPR12590] (ab173294) at 1/50000 dilution

Lane 1:

Human fetal heart lysate at 10 µg

Lane 2:

Human skeletal muscle lysate at 10 µg

Predicted band size: 101 kDa

false

  • Carrier free

    Anti-Sarcalumenin antibody [EPR12590] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR12590

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

style
left-column

Complementary Products

Primary Antibodies

AB195352

Anti-METTL3 antibody [EPR18810]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry - Anti-METTL3 antibody [EPR18810] (AB195352)

  • 5
  • 8
Primary Antibodies

AB188865

Anti-TXNIP antibody [EPR14774]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TXNIP antibody [EPR14774] (AB188865)

  • 4
  • 4
Primary Antibodies

AB200390

Anti-PARP7 antibody - N-terminal

  • 0
  • 0
Primary Antibodies

AB153914

Anti-NUR77 antibody

Western blot - Anti-NUR77 antibody (AB153914)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/50000 - 1/200000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
style
left-column

Product details

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

style
left-column

Properties and storage information

Form
Liquid
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Conditional Ambient
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Sarcalumenin is a calcium-binding protein with a molecular weight of approximately 160 kDa. It's also known as SRL. This protein is expressed mainly in the skeletal and cardiac muscle tissues where it populates the sarcoplasmic reticulum. Sarcalumenin plays a role in modulating calcium dynamics by storing and buffering calcium ions which is critical for muscle contraction and relaxation processes.
Biological function summary

This calcium-binding protein is involved in various muscle functions by being part of the sarcoplasmic reticulum membrane complex. Sarcalumenin assists in the regulation of calcium uptake and release essential for proper muscle function. It interacts with other proteins such as calsequestrin and triadin contributing to efficient calcium cycling which is necessary for rhythmic contractions of cardiac and skeletal muscles.

Pathways

Sarcalumenin plays an integral part in the calcium signaling pathway which is fundamental for muscle contraction and energy metabolism. It works closely with proteins like SERCA (Sarcoplasmic/Endoplasmic Reticulum Ca²⁺ ATPase) to facilitate the cycling of calcium ions across the sarcoplasmic reticulum. Furthermore it contributes to the excitation-contraction coupling pathway where its interaction with calsequestrin ensures synchronized muscle activity.

Altered expression or mutation of sarcalumenin has associations with cardiac-related conditions such as arrhythmias and cardiomyopathy. The protein's interaction with RyR2 (ryanodine receptor 2) highlights its role in these disorders. In skeletal muscles abnormalities in sarcalumenin function can lead to muscle fatigue and weakened contraction sometimes observed in myopathy patients. The balance and interaction with calsequestrin also suggest its involvement in maintaining muscle health.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

See full target information SRL
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 300:107426 PubMed38823637

2024

Circular RNA circMYLK4 shifts energy metabolism from glycolysis to OXPHOS by binding to the calcium channel auxiliary subunit CACNA2D2.

Applications

Unspecified application

Species

Unspecified reactive species

Haigang Cao,Chenchen Li,Xiaohui Sun,Jinjin Yang,Xiao Li,Gongshe Yang,Jianjun Jin,Xine Shi
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com