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AB137346

Anti-Sarcomeric Alpha Actinin antibody

5

(8 Reviews)

|

(65 Publications)

Anti-Sarcomeric Alpha Actinin antibody (ab137346) is a rabbit polyclonal antibody detecting Sarcomeric Alpha Actinin in Western Blot, IHC-P, ICC/IF. Suitable for Human, Mouse, Rat.

- Over 40 publications

View Alternative Names

Alpha-actinin-2, Alpha-actinin skeletal muscle isoform 2, F-actin cross-linking protein, ACTN2

15 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sarcomeric Alpha Actinin antibody (AB137346)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sarcomeric Alpha Actinin antibody (AB137346)

Immunohistochemical analysis of paraffin-embedded mouse heart tissue labelling Sarcomeric Alpha Actinin with ab137346 at 1/2000. Antigen retrieval : Citrate buffer, pH 6.0, 15 minutes.

Immunocytochemistry/ Immunofluorescence - Anti-Sarcomeric Alpha Actinin antibody (AB137346)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Sarcomeric Alpha Actinin antibody (AB137346)

Immunofluorescent analysis of ice-cold methanol fixed (5 minutes) HeLa cells labeling Sarcomeric Alpha Actinin with ab137346 at 1/500 dilution (4°C overnight), followed by Rabbit IgG antibody (Alexa Fluor 488) (keep from light) at 1/2000 dilution (room temperature for 1 hour) (green). Blue : Hoechst 33342 staining.

Blocking : 2.5% BSA/PBS for 30 minutes.

Washing : PBS, 3 x 3 minutes.

Immunocytochemistry/ Immunofluorescence - Anti-Sarcomeric Alpha Actinin antibody (AB137346)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Sarcomeric Alpha Actinin antibody (AB137346)

Immunofluorescence analysis of HeLa cells fixed in ice-cold MeOH for 5 min labelling alpha Actinin 2 protein at cytoskeleton using ab137346 at a 1/500 dilution (Green). DAPI was used for nuclear staining (Blue).

Immunocytochemistry/ Immunofluorescence - Anti-Sarcomeric Alpha Actinin antibody (AB137346)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Sarcomeric Alpha Actinin antibody (AB137346)

Immunofluorescence analysis of HeLa cells fixed in ice-cold MeOH for 5 min labelling alpha Actinin 2 protein at cytoskeleton using ab137346 at a 1/500 dilution (Green). DAPI was used for nuclear staining (Blue).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sarcomeric Alpha Actinin antibody (AB137346)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sarcomeric Alpha Actinin antibody (AB137346)

Immunohistochemical analysis of paraffin-embedded mouse muscle tissue stained for alpha Actinin 2 protein at cytoplasm with ab137346 at a 1/500 dilution.

Antigen retrieval : Citrate buffer, pH 6.0, 15 min

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sarcomeric Alpha Actinin antibody (AB137346)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sarcomeric Alpha Actinin antibody (AB137346)

Immunohistochemical analysis of paraffin-embedded rat muscle tissue stained for alpha Actinin 2 protein at cytoplasm in rat muscle with ab137346 at a 1/500 dilution.

Antigen retrieval : Citrate buffer, pH 6.0, 15 min

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sarcomeric Alpha Actinin antibody (AB137346)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sarcomeric Alpha Actinin antibody (AB137346)

Immunohistochemical analysis of paraffin-embedded mouse muscle tissue stained for alpha Actinin 2 protein at cytoplasm with ab137346 at a 1/500 dilution.

Antigen retrieval : Citrate buffer, pH 6.0, 15 min

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sarcomeric Alpha Actinin antibody (AB137346)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sarcomeric Alpha Actinin antibody (AB137346)

Immunohistochemical analysis of paraffin-embedded rat heart tissue labelling Sarcomeric Alpha Actinin with ab137346 at 1/2000. Antigen retrieval : Citrate buffer, pH 6.0, 15 minutes.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sarcomeric Alpha Actinin antibody (AB137346)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sarcomeric Alpha Actinin antibody (AB137346)

Immunohistochemical analysis of paraffin-embedded mouse heart tissue stained for alpha Actinin 2 protein at cytoplasm with ab137346 at a 1/500 dilution.

Antigen retrieval : Citrate buffer, pH 6.0, 15 min

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sarcomeric Alpha Actinin antibody (AB137346)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sarcomeric Alpha Actinin antibody (AB137346)

Immunohistochemical analysis of paraffin-embedded mouse muscle tissue stained for alpha Actinin 2 protein at cytoplasm with ab137346 at a 1/500 dilution.

Antigen retrieval : Citrate buffer, pH 6.0, 15 min

Western blot - Anti-Sarcomeric Alpha Actinin antibody (AB137346)
  • WB

Supplier Data

Western blot - Anti-Sarcomeric Alpha Actinin antibody (AB137346)

Samples were separated by 5% SDS-PAGE.

All lanes:

Western blot - Anti-Sarcomeric Alpha Actinin antibody (ab137346) at 1/1000 dilution

Lane 1:

293T whole cell extracts at 30 µg

Lane 2:

A431 whole cell extracts at 30 µg

Lane 3:

HeLa whole cell extracts at 30 µg

Lane 4:

HepG2 whole cell extracts at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG

Predicted band size: 103 kDa

false

Western blot - Anti-Sarcomeric Alpha Actinin antibody (AB137346)
  • WB

Supplier Data

Western blot - Anti-Sarcomeric Alpha Actinin antibody (AB137346)

Samples were separated by 5% SDS-PAGE.

All lanes:

Western blot - Anti-Sarcomeric Alpha Actinin antibody (ab137346) at 1/1000 dilution

Lane 1:

Neuro2A whole cell extracts at 30 µg

Lane 2:

NIH-3T3 whole cell extracts at 30 µg

Lane 2:

Raw264.7 whole cell extracts at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG

Predicted band size: 103 kDa

false

Western blot - Anti-Sarcomeric Alpha Actinin antibody (AB137346)
  • WB

Supplier Data

Western blot - Anti-Sarcomeric Alpha Actinin antibody (AB137346)

Samples were separated by 5% SDS-PAGE.

All lanes:

Western blot - Anti-Sarcomeric Alpha Actinin antibody (ab137346) at 1/100000 dilution

All lanes:

Mouse heart tissue extract at 50 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG

Predicted band size: 103 kDa

false

Western blot - Anti-Sarcomeric Alpha Actinin antibody (AB137346)
  • WB

Supplier Data

Western blot - Anti-Sarcomeric Alpha Actinin antibody (AB137346)

Samples were separated by 5% SDS-PAGE.

All lanes:

Western blot - Anti-Sarcomeric Alpha Actinin antibody (ab137346) at 1/20000 dilution

All lanes:

Rat heart tissue extract at 50 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG

Predicted band size: 103 kDa

false

Western blot - Anti-Sarcomeric Alpha Actinin antibody (AB137346)
  • WB

Supplier Data

Western blot - Anti-Sarcomeric Alpha Actinin antibody (AB137346)

Samples were separated by 7.5% SDS-PAGE.

All lanes:

Western blot - Anti-Sarcomeric Alpha Actinin antibody (ab137346) at 1/1000 dilution

All lanes:

Whole zebrafish extract at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 103 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human, Zebrafish

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ACTN2. The exact immunogen used to generate this antibody is proprietary information.

P35609

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/10000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p>Use ice-cold Methanol as fixation.</p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p>Suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).</p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/10000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p>Suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).</p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/10000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p>Suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).</p>" }, "Chicken": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Xenopus laevis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Xenopus tropicalis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Zebrafish": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/10000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Product details

What is this antibody validated in?
Anti-Sarcomeric Alpha Actinin antibody (ab137346) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples.

What is the molecular weight of Sarcomeric Alpha Actinin?
Anti-Sarcomeric Alpha Actinin (ab137346) specifically detects a band for Sarcomeric Alpha Actinin (UniProt: P35609) at a molecular weight of 103kDa.

Trusted by the scientific community
Anti-Sarcomeric Alpha Actinin (ab137346) was first used in a scientific publication in 2012 and has been cited over 40 times in peer-reviewed journals.

Reviewed by scientists
Anti-Sarcomeric Alpha Actinin (ab137346) has over 5 independent reviews from customers.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Sarcomeric Alpha Actinin often referred to as alpha-actinin or A-actinin is a protein that functions mechanically as a cross-linker of actin filaments in the sarcomere. It plays a critical role in organizing the actin cytoskeleton providing structural integrity and facilitating muscle contraction. The protein typically has a molecular mass of approximately 100 kDa. It is expressed in a variety of tissues including skeletal and cardiac muscle where it establishes the architecture of the Z-disc by anchoring actin filaments.
Biological function summary

Sarcomeric alpha actinin associates with multiple proteins to form a complex that coordinates muscle function. It not only serves as a structural component but also participates in signaling processes influencing muscle repair and growth. Alpha actinin connects to other cytoskeletal proteins and adaptors coordinating with integrin pathways to transmit external mechanical signals into cellular responses. The ability of alpha actinin to interact with a range of proteins like filamin and spectrin enhances its role in maintaining cellular architecture.

Pathways

Alpha actinin is critical in both the integrin and dystrophin-glycoprotein complex pathways facilitating signal transduction and maintaining muscle stability. Its interaction with actin filaments is important for pathways involving cell adhesion and motility. Within these pathways actin-related proteins such as ACTN2 and titin partner with alpha actinin to sustain cellular structure and function during dynamic processes including muscle contraction and relaxation.

Mutations or defects in alpha actinin have implications in muscular dystrophy and cardiomyopathy. These conditions often involve disruptions in the muscle's structural framework and mechanical signaling where alpha actinin's interaction with dystrophin becomes significant. Additionally such disorders may showcase altered connectivity between alpha actinin and spectrin further affecting muscle integrity and function in pathological conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
See full target information ACTN2
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Publications (65)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:7678 PubMed40825772

2025

Plant-derived hydrogel and photosynthetic nano-units for myocardial infarction therapy.

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Species

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YongBo Lv,Dashuai Zhu,Junlang Li,Yuan Li,Chao Lu,Jianing Bi,Ke Huang,Shiqi Hu,Shuo Liu,Na Yan,Ke Cheng,Juan Wang

Journal of cardiovascular development and disease 12: PubMed40710794

2025

Viability and Longevity of Human Miniaturized Living Myocardial Slices.

Applications

Unspecified application

Species

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Ziyu Zhou,Yvar P van Steenis,Surya Henry,Elisa C H van Doorn,Jorik H Amesz,Pieter C van de Woestijne,Natasja M S de Groot,Olivier C Manintveld,Beatrijs Bartelds,Yannick J H J Taverne

Journal of cellular and molecular medicine 29:e70733 PubMed40682481

2025

Myeloid MyD88 Mediates Macrophage Infiltration and Activation in Ang II-Induced Cardiac Hypertrophy.

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Ke Lin,Na Yang,Chenghong Hu,Wu Luo,Ping Huang,Guang Liang,Yi Wang

Nature communications 16:6668 PubMed40683882

2025

Cardiomyocyte OTUD1 drives diabetic cardiomyopathy via directly deubiquitinating AMPKα2 and inducing mitochondrial dysfunction.

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Xue Han,Ruyi Zheng,Jiajia Zhang,Yanan Liu,Ze Li,Guoxuan Liu,Jianing Zheng,Weiqi Li,Zijun Liang,Mengyang Wang,Jie Yu,Qiaojuan Shi,Huazhong Ying,Guang Liang

Physiological reports 13:e70420 PubMed40515433

2025

A comparison of human skeletal muscle cell maturation in 2D versus 3D culture: A quantitative proteomic study.

Applications

Unspecified application

Species

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Benjamin R Tollitt,Samantha W Jones,Jessica Ohana,James R Henstock,Malcolm J Jackson,Anne McArdle

Pharmaceuticals (Basel, Switzerland) 18: PubMed40283937

2025

Ginsenoside Rb Ameliorates Heart Failure Ventricular Remodeling by Regulating the Twist1/PGC-1α/PPARα Signaling Pathway.

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Ziwei Zhou,Zhimin Song,Xiaomeng Guo,Qi Wang,Meijing Li,Minyu Zhang,Muxin Gong

Nature 641:1017-1028 PubMed40269168

2025

BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury.

Applications

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Wei Ruan,Tao Li,In Hyuk Bang,Jaewoong Lee,Wankun Deng,Xinxin Ma,Cong Luo,Fang Du,Seung-Hee Yoo,Boyun Kim,Jiwen Li,Xiaoyi Yuan,Katherine Figarella,Yu A An,Yin-Ying Wang,Yafen Liang,Matthew DeBerge,Dongze Zhang,Zhen Zhou,Yanyu Wang,Joshua M Gorham,Jonathan G Seidman,Christine E Seidman,Sary F Aranki,Ragini Nair,Lei Li,Jagat Narula,Zhongming Zhao,Alemayehu A Gorfe,Jochen D Muehlschlegel,Kuang-Lei Tsai,Holger K Eltzschig

British journal of pharmacology 182:2560-2581 PubMed39965654

2025

Imatinib aggravates pressure-overload-induced right ventricle failure via JNK/Runx2 pathway.

Applications

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Species

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Xiaohui Zeng,Zhuoji Ma,Shanshan Wen,Liang Zhou,Wanxian Hong,Zhixiong Wu,Chunxian Cen,Qianwen Bai,Shangwei Ding,Xin Chen,Jian Wang,Lingdan Chen,Wenju Lu,Tao Wang

Molecular medicine (Cambridge, Mass.) 31:42 PubMed39905300

2025

TAB2 deficiency induces dilated cardiomyopathy by promoting mitochondrial calcium overload in human iPSC-derived cardiomyocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Wenrui Sun,Jianchao Zhang,Shuang Li,Wanrong Fu,Yangyang Liu,Mengduan Liu,Jianzeng Dong,Xiaoyan Zhao,Xiaowei Li

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e2415303 PubMed39887582

2025

Near Infrared-Mediated Intracellular NADH Delivery Strengthens Mitochondrial Function and Stability in Muscle Dysfunction Model.

Applications

Unspecified application

Species

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Hui Bang Cho,Hye-Ryoung Kim,Sujeong Lee,Chae Won Cho,Ji-In Park,Seulki Youn,Gyuwon So,Sumin Kang,Hye Jin Kim,Keun-Hong Park
View all publications
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Product promise

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