Anti-Sarcosine Oxidase/PSO antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Sarcosine Oxidase also referred to as PSO is an enzyme with a known molecular mass of approximately 120 kDa. It functions mechanically as a flavoprotein oxidase. Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine converting it into glycine formaldehyde and hydrogen peroxide. This enzyme is commonly expressed in microbial species including various bacteria like Pseudomonas. Sarcosine oxidase consists of multiple subunits and its active form typically includes both small and large subunits.

Biological function summary

Sarcosine oxidase plays an important role in the one-carbon metabolism specifically involved in glycine and sarcosine degradation pathways. It does not form a part of any known large protein complex but it associates with the biochemical pathway that generates formaldehyde. This pathway is significant for its contribution to the cellular pool of one-carbon units which are important for biosynthetic processes like nucleic acids and certain amino acids synthesis.

Pathways

Sarcosine oxidase is involved in the degradation of glycine and sarcosine pathways. These pathways are parts of the one-carbon metabolism network. The enzyme's activity supports the transfer and utilization of one-carbon units in folate-dependent processes. It connects with related enzymes such as glycine decarboxylase which further regulates the flow of one-carbon compounds within the cell. The importance of these pathways lies in their role in maintaining the cellular methylation status and energy metabolism.

Associated diseases and disorders

Sarcosine oxidase has been associated with prostate cancer and metabolic disorders like nonketotic hyperglycinemia. Increased levels of sarcosine have been linked to prostate cancer progression suggesting its potential as a biomarker. In these conditions the enzyme's activity or misregulation interplays with proteins like glycine N-methyltransferase which control one-carbon metabolism and cellular methylation reactions. Understanding these connections might offer insights into therapeutic targets for managing relevant disorders.