Rabbit Polyclonal SARDH antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SARDH aa 450-600.
View Alternative Names
DMGDHL1, SARDH, SarDH, BPR-2
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARDH antibody (AB188521)
Paraffin embedded human kidney tissue stained for SARDH using ab188521 at 1/1000 dilution in immunohistochemical analysis.
Heat mediated antigen retrieval was performed with citrate buffer pH 6 before the IHC staining protocol.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARDH antibody (AB188521)
Paraffin embedded human pancreas tissue stained for SARDH using ab188521 at 1/1000 dilution in immunohistochemical analysis.
Heat mediated antigen retrieval was performed with citrate buffer pH 6 before the IHC staining protocol.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARDH antibody (AB188521)
Immunohistochemical analysis of formalin fixed paraffin embedded human liver tissue labeling SARDH with ab188521 at 1/1000 dilution.
Heat mediated antigen retrieval was performed with citrate buffer pH 6 before the IHC staining protocol.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARDH antibody (AB188521)
Paraffin embedded human prostate tissue stained for SARDH using ab188521 at 1/1000 dilution in immunohistochemical analysis.
Heat mediated antigen retrieval was performed with citrate buffer pH 6 before the IHC staining protocol.
- WB
Supplier Data
Western blot - Anti-SARDH antibody (AB188521)
All lanes:
Western blot - Anti-SARDH antibody (ab188521) at 1/250 dilution
Lane 1:
RT4 cell lysate
Lane 2:
U-251 MG sp cell lysate
Lane 3:
Human plasma (IgG/HSA depleted)
Lane 4:
Human liver tissue
Predicted band size: 101 kDa
false
Reactivity data
Properties and storage information
Form
Purification technique
Storage buffer
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Sarcosine dehydrogenase is responsible for maintaining the balance of sarcosine and related metabolites. By converting sarcosine to glycine SARDH plays a role in the methionine cycle and folate-mediated one-carbon metabolism. This enzyme does not function as part of a larger protein complex but interacts independently within cellular metabolism processes. Proper functioning of SARDH helps in the regulation of cellular methylation reactions as it is interconnected with other metabolic pathways that manage methyl groups.
Pathways
SARDH is an important component of the glycine and serine metabolism pathway. This pathway is integral to the one-carbon metabolic network which is important for nucleic acid synthesis and cell division. SARDH is related to other enzymes like dimethylglycine dehydrogenase (DMGDH) through the catabolic processes of different methylated amino acids. Additionally it participates in the methionine cycle closely linked with enzymes such as methionine synthase emphasizing its interconnectedness in maintaining amino acid homeostasis.
Product protocols
- Visit the General protocols
- Visit the Troubleshooting
Target data
Publications (1)
Recent publications for all applications. Explore the full list and refine your search
The Tohoku journal of experimental medicine : PubMed41062300
2025
Applications
Unspecified application
Species
Unspecified reactive species
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com