Anti-SARS-CoV-2 (COVID-19) nsp10 antibody [HL1381] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SARS-CoV-2 nonstructural protein 10 (nsp10) also known as growth factor-like protein 1 acts mechanically as a cofactor to enhance the activity of nsp14 and nsp16. Nsp10 with a molecular mass of approximately 14 kDa facilitates the methylation of viral RNA which is important for viral replication and evasion of the host immune response. This protein expresses in the host cells infected by the virus particularly in the cytoplasm where viral replication occurs.

Biological function summary

The interaction of nsp10 with other viral proteins is essential for the virus's lifecycle. Nsp10 forms a complex with nsp14 a proofreading exonuclease and nsp16 a 2'-O-methyltransferase. This complex ensures the integrity and stability of viral RNA by capping and proofreading protecting it from host immune detection. By forming this complex nsp10 supports the efficient replication and transcription of viral RNA an important process for SARS-CoV-2 infection and propagation in the host.

Pathways

Nsp10 participates in viral replication and host immune evasion strategies. It is integral to the RNA capping and modification pathways ensuring that SARS-CoV-2 RNA is efficiently transcribed and translated. This protein interacts particularly with nsp14 and nsp16 aiding in the proper assembly of the replication-transcription complex. These interactions allow the virus to maintain its genomic fidelity and to avoid the immune response important for successful infection.

Associated diseases and disorders

Nsp10 has a significant role in the pathogenesis of COVID-19 the disease caused by SARS-CoV-2. It influences the severity of the disease by facilitating effective viral replication and immune evasion strategies. Additionally research indicates links between nsp10 and other respiratory diseases highlighting its role in viral pathogenesis. The interaction of nsp10 with proteins like nsp14 positions it as a potential target for therapeutic intervention to disrupt its function and combat COVID-19 effectively.