Anti-SARS CoV 2 COVID 19 nsp9 antibody [HL1399]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SARS-CoV-2 nsp9 also known as non-structural protein 9 plays an important role in viral replication. With a molecular weight of approximately 12 kDa this protein is integral to the replication and transcription complex of SARS-CoV-2 and is expressed during viral infection within host cells. Nsp9 facilitates the synthesis of RNA by binding to single-stranded RNA. This unique RNA-binding feature distinguishes it from other viral proteins implying its specific function in sustaining the viral genome.

Biological function summary

Nsp9 contributes significantly to the process of viral RNA replication. It functions within a complex that includes other non-structural proteins forming a multi-protein assembly necessary for efficient genome replication. This process ensures the viral RNA is correctly copied and translated therefore maintaining the infectivity of SARS-CoV-2. Nsp9's contribution to RNA binding and stabilization plays an important role in controlling the replication accuracy and speed of the virus.

Pathways

Nsp9 participates in the viral replication and transcription pathways of SARS-CoV-2. It interacts closely with proteins like nsp7 and nsp8 which are also a part of the replication machinery. These interactions within the RNA synthesis pathway facilitate the continuous production of viral components sustaining the life cycle of the virus within the host. Understanding these pathways provides insights into potential therapeutic targets to disrupt viral replication.

Associated diseases and disorders

Nsp9 features prominently in COVID-19 the disease caused by SARS-CoV-2 infection. The protein's role in replication links it to the spread and severity of the infection. Targeting nsp9 could serve as a potential strategy for antiviral therapies. Moreover its interactions with other non-structural proteins such as nsp12 RNA-dependent RNA polymerase highlight the interconnectedness of these proteins in the progression of SARS-CoV-2-related pathology.