Anti-SARS-CoV-2 nsp15 antibody [HL1445] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SARS-CoV-2 nsp15 also known as non-structural protein 15 is an endoribonuclease with uridine-specific activity. It is expressed in the cytoplasm of cells infected by the virus. Nsp15 has a monomer mass of approximately 42 kDa. In its active form it typically assembles into a hexameric complex which is important for its enzymatic function. It helps in evading the host immune response by degrading double-stranded RNA intermediates preventing detection by the host's antiviral pathways.

Biological function summary

Nsp15 is an important participant in the viral replication machinery of SARS-CoV-2. Nsp15 as part of the replication and transcription complex processes viral RNA to promote efficient replication. This protein may interact indirectly with other non-structural proteins such as nsp8 and nsp12 which form part of the RNA-dependent RNA polymerase complex. By maintaining the integrity of viral RNA nsp15 ensures successful virus propagation.

Pathways

Nsp15 plays a significant role in the viral life cycle particularly in the genome replication and transcription pathways. This protein is connected to nsp10 and nsp14 which are involved in RNA proofreading and capping. These interactions support the virus in overcoming innate immune responses by ensuring proper RNA processing and replication. Through these pathways nsp15 contributes significantly to the viral survival and proliferation within the host.

Associated diseases and disorders

Nsp15 is primarily linked to COVID-19. Its role in immune evasion makes it a target of interest in the study of viral pathogenesis and therapeutic interventions. Research has indicated potential interactions between nsp15 and host proteins that could impact disease progression. Furthermore its manipulation or inhibition could serve as a therapeutic strategy potentially reducing the ability of SARS-CoV-2 to spread within the host. Understanding these interactions could aid in the development of antiviral drugs targeting nsp15 specifically.