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AB31951

Anti-SARS E2 antibody [4A6C9] - Coronavirus

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(1 Publication)

Mouse Monoclonal SARS E2 antibody. Suitable for ELISA, WB and reacts with SARS-CoV samples. Cited in 1 publication.
1 Images
Western blot - Anti-SARS E2 antibody [4A6C9] - Coronavirus (AB31951)
  • WB

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Western blot - Anti-SARS E2 antibody [4A6C9] - Coronavirus (AB31951)

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MW Marker

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Western blot - Anti-SARS E2 antibody [4A6C9] - Coronavirus (ab31951) at 1/2000 dilution

All lanes:

SARS E2 Recombinant protein

Observed band size: 36 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

4A6C9

Isotype

IgG1

Carrier free

No

Reacts with

SARS-CoV

Applications

WB, ELISA

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "SARS-CoV": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/5000", "WB-species-notes": "<p></p>" } } }
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Product details

Applications overview

Tick: Tested and Guaranteed to work X: Will not work —: No data

<img src="https://www.abcam.com/ps/Products/31/ab31951/Images/ab31951-394524-applications-overview.jpg" height="125" width="677">

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purified from tissue culture supernatant.
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The SARS E2 protein also known as the envelope or E protein is a structural component of the SARS coronavirus. It has a molecular mass of about 8.4 kDa. The E2 protein is expressed on the envelope of the SARS coronavirus where it plays an important role in virus assembly budding and pathogenesis. This protein assists in the formation of the viral envelope by interacting with other viral components and host cell membranes facilitating the release of new virions from the host cell.
Biological function summary

The SARS E2 protein functions in the assembly of virions and is part of a larger viral protein complex. This protein is involved in the regulation of the host's intracellular membrane trafficking which impacts viral replication and release. The E2 protein exhibits ion channel activity known as a viroporin influencing various host cellular processes including stress response and apoptosis.

Pathways

The SARS E2 protein interacts with early endosomal and Golgi pathways which are critical for viral trafficking within the host cell. It shares functional relations with other SARS coronavirus proteins such as the M (membrane) and S (spike) proteins. These interactions allow the virus to efficiently package and release infectious particles. The E2 protein also influences pathways associated with inflammation and immune evasion contributing to the virus's ability to persist and cause disease.

The SARS E2 protein is directly associated with severe acute respiratory syndrome (SARS) and coronavirus disease (COVID-19). Its interaction with the host cell's pathways can exacerbate inflammation and immune dysfunction leading to severe respiratory symptoms. Connections exist between the E2 protein and proteins involved in the host's inflammatory response such as cytokines which can result in a cytokine storm a critical factor in disease progression and severity in SARS and COVID-19 patients.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information SARS E2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 11:738078 PubMed34604081

2021

Ceramide Regulates Anti-Tumor Mechanisms of Erianin in Androgen-Sensitive and Castration-Resistant Prostate Cancers.

Applications

Unspecified application

Species

Unspecified reactive species

I Gusti Md Gde Surya C Trapika,Xin Tracy Liu,Long Hoa Chung,Felcia Lai,Chanlu Xie,Yang Zhao,Shaohui Cui,Jinbiao Chen,Collin Tran,Qian Wang,Shubiao Zhang,Anthony S Don,George Qian Li,Jane R Hanrahan,Yanfei Qi
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Product promise

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