Rabbit Polyclonal SARS2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SARS2.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human SARS2. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NP81
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/1000.00000 | Notes - |
Target data
Function
Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
Alternative names
SARSM, SARS2, SerRSmt, Seryl-tRNA synthetase, Seryl-tRNA(Ser/Sec) synthetase, SerRS
Recommended products
Rabbit Polyclonal SARS2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SARS2.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human SARS2. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NP81
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SARS2 also known as angiotensin-converting enzyme 2 (ACE2) plays an important role in converting angiotensin II into angiotensin 1-7 a peptide that affects blood pressure and fluid balance. This protein has a mass of approximately 120 kDa and is expressed in various tissues including the lungs heart kidneys and gastrointestinal tract. ACE2 serves as a functional receptor for the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which allows viral entry into host cells.
- Biological function summary
SARS2 regulates cardiovascular and renal functions and maintains the renin-angiotensin system (RAS). It is a part of a counter-regulatory mechanism alongside other components like angiotensin-converting enzyme (ACE). ACE2 contributes greatly to the modulation of RAS by balancing the effects of angiotensin II through its breakdown into angiotensin 1-7. These actions protect organs from damage that could be caused by angiotensin II-related stresses.
- Pathways
SARS2 is deeply involved in both the RAS and the kallikrein-kinin system. These pathways control blood pressure electrolyte balance and inflammation. Within the RAS SARS2 works closely with ACE and also impacts kinins levels through the kallikrein-kinin system. Such interactions make SARS2 important in both systemic and local cellular effects in different tissues.
- Associated diseases and disorders
SARS2's role in COVID-19 is notable as it serves as the entry point for the SARS-CoV-2 virus that causes the disease. Additionally its involvement in blood pressure regulation links it to hypertension. The connection with SARS-CoV-2 highlights interactions with spike protein which enhances the understanding of COVID-19's pathology. Hypertension studies point to the interplay with angiotensin II highlighting SARS2's significance in cardiovascular health.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
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3 product images
Western blot - Anti-SARS2 antibody (ab229227)
7.5% SDS-PAGE gel.
All lanes: Western blot - Anti-SARS2 antibody (ab229227) at 1/1000 dilution
All lanes: U-87 MG (human glioblastoma-astrocytoma epithelial cell line) whole cell lysate at 30 µg
Predicted band size: 58 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARS2 antibody (ab229227)
Paraffin-embedded human hepatoma tissue stained for SARS2 using ab229227 at 1/500 dilution in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARS2 antibody (ab229227)
Paraffin-embedded human lung carcinoma tissue stained for SARS2 using ab229227 at 1/250 dilution in immunohistochemical analysis.
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