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AB229227

Anti-SARS2 antibody

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(2 Publications)

Rabbit Polyclonal SARS2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SARS2.

View Alternative Names

SARSM, SARS2, SerRSmt, Seryl-tRNA synthetase, Seryl-tRNA(Ser/Sec) synthetase, SerRS

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARS2 antibody (AB229227)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARS2 antibody (AB229227)

Paraffin-embedded human lung carcinoma tissue stained for SARS2 using ab229227 at 1/250 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARS2 antibody (AB229227)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARS2 antibody (AB229227)

Paraffin-embedded human hepatoma tissue stained for SARS2 using ab229227 at 1/500 dilution in immunohistochemical analysis.

Western blot - Anti-SARS2 antibody (AB229227)
  • WB

Supplier Data

Western blot - Anti-SARS2 antibody (AB229227)

7.5% SDS-PAGE gel.

All lanes:

Western blot - Anti-SARS2 antibody (ab229227) at 1/1000 dilution

All lanes:

U-87 MG (human glioblastoma-astrocytoma epithelial cell line) whole cell lysate at 30 µg

Predicted band size: 58 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SARS2. The exact immunogen used to generate this antibody is proprietary information.

Q9NP81

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SARS2 also known as angiotensin-converting enzyme 2 (ACE2) plays an important role in converting angiotensin II into angiotensin 1-7 a peptide that affects blood pressure and fluid balance. This protein has a mass of approximately 120 kDa and is expressed in various tissues including the lungs heart kidneys and gastrointestinal tract. ACE2 serves as a functional receptor for the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which allows viral entry into host cells.
Biological function summary

SARS2 regulates cardiovascular and renal functions and maintains the renin-angiotensin system (RAS). It is a part of a counter-regulatory mechanism alongside other components like angiotensin-converting enzyme (ACE). ACE2 contributes greatly to the modulation of RAS by balancing the effects of angiotensin II through its breakdown into angiotensin 1-7. These actions protect organs from damage that could be caused by angiotensin II-related stresses.

Pathways

SARS2 is deeply involved in both the RAS and the kallikrein-kinin system. These pathways control blood pressure electrolyte balance and inflammation. Within the RAS SARS2 works closely with ACE and also impacts kinins levels through the kallikrein-kinin system. Such interactions make SARS2 important in both systemic and local cellular effects in different tissues.

SARS2's role in COVID-19 is notable as it serves as the entry point for the SARS-CoV-2 virus that causes the disease. Additionally its involvement in blood pressure regulation links it to hypertension. The connection with SARS-CoV-2 highlights interactions with spike protein which enhances the understanding of COVID-19's pathology. Hypertension studies point to the interplay with angiotensin II highlighting SARS2's significance in cardiovascular health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
See full target information SARS2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Stem cell research & therapy 15:316 PubMed39304926

2024

MSC-extracellular vesicle microRNAs target host cell-entry receptors in COVID-19: in silico modeling for in vivo validation.

Applications

Unspecified application

Species

Unspecified reactive species

Hajer A Al Saihati,Arigue A Dessouky,Rabab F Salim,Islam Elgohary,Mohamed El-Sherbiny,Fares E M Ali,Mahmoud M A Moustafa,Dalia Shaheen,Nicholas Robert Forsyth,Omnia A Badr,Nesrine Ebrahim

Neural plasticity 2022:3172861 PubMed35237315

2022

Preferential Involvement of BRCA1/BARD1, Not Tip60/Fe65, in DNA Double-Strand Break Repair in Presenilin-1 P117L Alzheimer Models.

Applications

Unspecified application

Species

Unspecified reactive species

Marcella M Authiat,Emmanuelle Gruz-Gibelli,Julien Colas,Estelle Bianchi,Marta Garcia-Arauzo,Pascale Marin,François R Herrmann,Armand Savioz
View all publications
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