Anti-SBF2 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SBF2 also known as SET binding factor 2 or pseudophosphatase MTMR13 is a protein with a molecular weight of approximately 150 kDa. It functions as a pseudophosphatase which means it lacks catalytic activity typically seen in phosphatases but can still play a regulatory role. SBF2 shows strong expression in nervous tissue particularly in Schwann cells which are essential for peripheral nerve function. The protein contains a coiled-coil domain that may facilitate interactions with other proteins or cellular components.

Biological function summary

SBF2 participates in cellular processes linked to endocytosis the pathway that internalizes cell surface receptors and other molecules. It serves as part of a complex with active phosphatases like MTMR2 modulating their action and localization in the cell. Through these interactions SBF2 exerts influence over cellular homeostasis and membrane trafficking although the exact mechanisms are not fully understood. Despite its lack of enzymatic function it remains significant in organizing cellular responses that demand rapid adaptation.

Pathways

SBF2 contributes to the phosphatidylinositol signaling pathways affecting how cells perceive and react to external signals. In this manner it assists in the regulation of protein interactions for signal transduction. Together with MTMR2 SBF2 influences phosphatidylinositol 3-phosphate levels and modulates trafficking of endosomal proteins. It carries a role in directing cellular components and maintaining the clarity of signaling messages that depend on precise molecular feedback.

Associated diseases and disorders

Mutations or dysregulation of SBF2 directly correlate with Charcot-Marie-Tooth disease type 4B a hereditary neuropathy characterized by demyelination. The condition affects peripheral nerves and connects SBF2 to dysfunction in myelin sheath maintenance. During these pathological states SBF2 often shows altered interactions with MTMR2 leading to disrupted myelin homeostasis. Understanding the role of SBF2 in these contexts paves a path to potential therapeutic strategies targeting neuropathic conditions involving impaired cellular signaling and protein trafficking.