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AB232771

Anti-SBSN antibody

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(4 Publications)

Rabbit Polyclonal SBSN antibody. Suitable for WB and reacts with Human, Pig, Recombinant full length protein - Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SBSN aa 400 to C-terminus.

View Alternative Names

UNQ698/PRO1343, SBSN, Suprabasin

2 Images
Western blot - Anti-SBSN antibody (AB232771)
  • WB

Supplier Data

Western blot - Anti-SBSN antibody (AB232771)

All lanes:

Western blot - Anti-SBSN antibody (ab232771) at 1 µg/mL

All lanes:

Recombinant human SBSN protein

Secondary

All lanes:

HRP-Linked Guinea pig Anti-Rabbit at 1/2000 dilution

Predicted band size: 25 kDa

false

Western blot - Anti-SBSN antibody (AB232771)
  • WB

Supplier Data

Western blot - Anti-SBSN antibody (AB232771)

All lanes:

Western blot - Anti-SBSN antibody (ab232771) at 1 µg/mL

Lane 1:

Human serum

Lane 2:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate

Lane 3:

Human urine

Lane 4:

Pig skin tissue lysate

Secondary

All lanes:

HRP-Linked Guinea pig Anti-Rabbit at 1/2000 dilution

Predicted band size: 25 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Pig

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human SBSN aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6UWP8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>" }, "Recombinant full length protein - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SBSN also known as suprabasin is a protein with a molecular weight of approximately 55 kDa. It plays a mechanical role in maintaining cell adhesion and integrity. SBSN localizes mainly in the epidermis and oral epithelia where it contributes to skin barrier function. In addition its expression appears in other stratified squamous epithelia tissues indicating its general role in epidermal formation and maintenance.
Biological function summary

SBSN contributes to the formation and maintenance of the epithelial barrier. It acts as a component within specialized structures such as desmosomes which are important for cell-cell adhesion in epithelial tissues. The protein works alongside other structural proteins to maintain cellular cohesion and prevent damage from mechanical stress. SBSN interacts with components such as keratin highlighting its integration within the cytoskeletal framework necessary for normal epithelial function.

Pathways

Several cellular processes involve SBSN notably those linked to skin development and repair. It plays a role in the Wnt signaling pathway which is important for skin cell proliferation and differentiation. Furthermore SBSN interacts with other proteins in the pathway such as β-catenin indicating its role in cell signaling. SBSN also participates in pathways governing desmosome assembly further emphasizing its structural role.

SBSN has associations with several skin-related conditions notably psoriasis and squamous cell carcinoma. The protein’s altered expression or dysfunction can disrupt epidermal cohesion and barrier function contributing to the pathogenesis of these diseases. In the context of squamous cell carcinoma SBSN expression may interact with proteins like p53 impacting apoptotic regulation and tumorigenicity. Its involvement in such conditions makes it a potential target for therapeutic strategies aimed at modulating its function or expression in diseased states.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information SBSN
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Journal of otology 19:133-139 PubMed39735238

2024

Loss of Fascin2 increases susceptibility to cisplatin-induced hearing impairment and cochlear cell apoptosis in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Wang,Yingying Liu,Yi Xie,Jun Luan,Rongrong Liu,Yongjia Zhu,Ying Ma,Yi Fan,Yan Sun,Wenjing Shang,Fengchan Han

Oncology reports 49: PubMed36896786

2023

Suprabasin enhances the invasion, migration, and angiogenic ability of oral squamous cell carcinoma cells under hypoxic conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Asami Houri,Yoshiki Mukudai,Yuzo Abe,Masataka Watanabe,Maki Nara,Saya Miyamoto,Mai Kurihara,Toshikazu Shimane,Tatsuo Shirota

British journal of cancer 127:211-222 PubMed35484216

2022

SBSN drives bladder cancer metastasis via EGFR/SRC/STAT3 signalling.

Applications

Unspecified application

Species

Unspecified reactive species

Zhongqiu Zhou,Zhuojun Zhang,Han Chen,Wenhao Bao,Xiangqin Kuang,Ping Zhou,Zhiqing Gao,Difeng Li,Xiaoyi Xie,Chunxiao Yang,Xuhong Chen,Jinyuan Pan,Ruiming Tang,Zhengfu Feng,Lihuan Zhou,Lan Wang,Jianan Yang,Lili Jiang

Oncology reports 40:2854-2863 PubMed30226544

2018

Dermcidin as a novel binding protein of lncRNA STCAT3 and its effect on prognosis in gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jianfeng Zhang,Weifeng Ding,Xiaoling Kuai,Yimin Ji,Zhenglong Zhu,Zhenbiao Mao,Zhiwei Wang
View all publications
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Product promise

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