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AB96305

Anti-SCAMP3/SC3 antibody

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(1 Publication)

Rabbit Polyclonal SCAMP3/SC3 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SCAMP3 aa 1-150.

View Alternative Names

C1orf3, PROPIN1, SCAMP3, Secretory carrier-associated membrane protein 3, Secretory carrier membrane protein 3

1 Images
Western blot - Anti-SCAMP3/SC3 antibody (AB96305)
  • WB

Unknown

Western blot - Anti-SCAMP3/SC3 antibody (AB96305)

12% SDS PAGE

All lanes:

Western blot - Anti-SCAMP3/SC3 antibody (ab96305) at 1/2000 dilution

All lanes:

Molt-4 whole cell lysate at 30 µg

Predicted band size: 38 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human SCAMP3 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

O14828

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCAMP3 also known as Secretory Carrier-Associated Membrane Protein 3 weighs approximately 38 kDa. It is a member of the SCAMP family characterized by several cytoplasmic domains and transmembrane regions. SCAMP3 is expressed in various tissues with notable expression in kidney lung and brain tissue. Mechanically it participates in membrane trafficking within cells particularly involved in processes of endocytosis and recycling of membrane proteins.
Biological function summary

SCAMP3 plays a role in the trafficking of proteins between cell compartments. It is part of the protein complex that facilitates efficient recycling of receptors and other proteins from endosomes back to the plasma membrane or towards lysosomal degradation pathways. SCAMP3 influences the endocytic pathway efficiency and impacts cellular activities such as signal transduction and nutrient intake.

Pathways

SCAMP3 functions in the endosomal trafficking pathway and is associated with the epidermal growth factor receptor (EGFR) signaling pathway. It works alongside proteins like Eps15 and AP-2 adapter protein to help modulate the sorting and recycling of endocytosed proteins. SCAMP3 is critical in determining the routing of internalized cargo which impacts signaling pathway duration and intensity.

SCAMP3 has been linked to neurodegenerative disorders and certain types of cancer. Altered SCAMP3 expression can interfere with protein trafficking contributing to pathological conditions like Alzheimer’s disease. Furthermore its relationship with EGFR ties SCAMP3 to oncogenic processes where dysregulation is often seen in lung cancer. Proteins such as EGFR and amyloid precursor protein (APP) exhibit pathological connections with SCAMP3 in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.
See full target information SCAMP3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 5:76 PubMed35058562

2022

Citrin mediated metabolic rewiring in response to altered basal subcellular Ca homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Zhanat Koshenov,Furkan E Oflaz,Martin Hirtl,Benjamin Gottschalk,Rene Rost,Roland Malli,Wolfgang F Graier
View all publications
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Product promise

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